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Details for Professor Clive Orchard

Personal details
Name Professor Clive Orchard
Job title Professor
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BSc, PhD(Lond), DSc
Professional details
Membership of professional bodies British Society for Cardiovascular Research
The Physiological Society (President 2008-10)
Biophysical Society (U.S.A.)
International Society for Heart Research
Fellow of the Society of Biology
Keywords cardiac excitation-contraction coupling
intracellular Ca2+
intracellular messenger pathways
t-tubules
cardiac ventricular myocytes
surface membrane
ion handling
Areas of expertise My research is focused on cardiac excitation-contraction coupling and its regulation. Using a variety of techniques (for example voltage clamp, fluorescent ion indicators,whole cell and confocal microscopy, immunohistochemistry, RT-PCR and computer modelling) we are investigating how the rise of intracellular Ca2+ that causes contraction is initiated, and how it is regulated by intracellular 2nd messenger pathways. A particular interest is the role of the t-tubules (invaginations of the surface membrane of cardiac ventricular myocytes) in this process. We have recently developed a technique that allows us to physically and functionally uncouple the t-tubules from the surface membrane, enabling us to investigate their function. Using this technique we have been able to show that the t-tubules form a specialised region of the cell membrane for ion handling.