Directory of Experts

Details for Professor Clive Orchard

Personal details
Name Professor Clive Orchard
Job title Professor
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office.

work+44 (0)117 331 8092
Qualifications BSc, PhD(Lond), DSc
Professional details
Membership of professional bodies British Society for Cardiovascular Research
The Physiological Society (President 2008-10)
Biophysical Society (U.S.A.)
International Society for Heart Research
Fellow of the Society of Biology
Keywords cardiac excitation-contraction coupling
intracellular Ca2+
intracellular messenger pathways
cardiac ventricular myocytes
surface membrane
ion handling
Areas of expertise My research is focused on cardiac excitation-contraction coupling and its regulation. Using a variety of techniques (for example voltage clamp, fluorescent ion indicators,whole cell and confocal microscopy, immunohistochemistry, RT-PCR and computer modelling) we are investigating how the rise of intracellular Ca2+ that causes contraction is initiated, and how it is regulated by intracellular 2nd messenger pathways. A particular interest is the role of the t-tubules (invaginations of the surface membrane of cardiac ventricular myocytes) in this process. We have recently developed a technique that allows us to physically and functionally uncouple the t-tubules from the surface membrane, enabling us to investigate their function. Using this technique we have been able to show that the t-tubules form a specialised region of the cell membrane for ion handling.