Directory of Experts
Details for Dr Jon Brown
| Personal details | |
| Name | Dr Jon Brown |
| Job title | Visiting Fellow |
| Department | School of Physiology and Pharmacology University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
| Qualifications | BSc, MRes, PhD(Bristol) |
| Professional details | |
| Keywords | electrophysiology synapse excitability networks hippocampus prefrontal cortex schizophrenia Alzheimer's disease |
| Areas of expertise | Prefrontal and hippocampal neurophysiology in models of schizophrenia. Subtle changes in neurodevelopment, which result in biochemical, structural, neurophysiological and ultimately behavioural deficits, contribute to the symptoms of schizophrenia. In particular, cortical and limbic regions such as the prefrontal cortex and hippocampus appear to be affected. In collaboration with Pfizer, we are using a range of neurodevelopmental models of schizophrenia to investigate the neurophysiological basis of this condition, using brain slices prepared from the prefrontal cortex and hippocampus. The neurophysiology of ageing. The normal ageing process results in changes to cognitive function which contributes to the reduced quality of life often experienced by the elderly. However, the neurophysiological bases of these impairments are not understood. In collaboration with Nina Balthasar, Neil Marrion, Richard Apps and Matt Jones, we are studying the effects of ageing on ion channel function and neuroexcitability. |