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Details for Dr Kara Ranaghan

Personal details
Name Dr Kara Ranaghan
Job title Senior Research Associate
Department School of Chemistry University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications MSc(Bristol), PhD(Bristol)
Professional details
Keywords enzyme mechanism
phosphite oxidation
Areas of expertise I became interested in studying enzyme mechanisms as an undergraduate project student and have now spent several years using computational techniques to explore aspects of enzyme reaction mechanisms and catalysis, focusing on the enzymes chorismate mutase, aromatic amine dehydrogenase, and methylamine dehydrogenase. How these enzymes achieve catalysis is at the centre of much lively debate: such as the role of tunnelling in enzyme reactions.

My current project involves studying the reaction mechanism of phosphite oxidation in phosphite dehydrogenase (PTDH).