Directory of Experts

Details for Dr Alexander Greenhough

Personal details
Name Dr Alexander Greenhough
Job title Senior Research Associate
Senior Research Associate
Department School of Cellular and Molecular Medicine University of Bristol
School of Cellular and Molecular Medicine University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office.

work+44 (0)117 331 8092
email:
Qualifications BSc(Warw), PhD(Bristol)
Professional details
Keywords tumour cell survival
colorectal cancer cell biology and chemoprevention
hypoxia and the tumour microenvironment
beta-catenin
transcription factors
apoptosis and autophagy
HIF-1
COX-2, prostaglandins, NSAID and aspirin
Areas of expertise Tumour cell survival mechanisms and colorectal cancer chemoprevention.

Context-dependent roles for beta-catenin, HIF-1 and COX-2 during adaptive cellular responses to the hypoxic/hypoglycaemic tumour microenvironment.

Genome-wide analysis of transcription factor binding sites and gene expression under conditions of cellular stress.

Pleiotropic effects of COX-2/PGE2 signalling.

Mechanisms underlying suppression of apoptosis and oncogene addiction.

Regulation of BH3-only proteins by Raf-MEK-ERK1/2 and PI3K-Akt survival signalling cascades.

Novel regulators of microenvironment-driven autophagy and its divergent roles in tumorigenesis.