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Details for Professor Pete Cullen

Personal details
Name Professor Pete Cullen
Job title Professor of Biochemistry (Royal Society Wolfson Research Merit Award Holder)
Department School of Biochemistry University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications BSc, PhD(EAnglia)
Professional details
Membership of professional bodies British Society for Cell Biology
Biochemical Society
Member of the Lister Institute
Keywords phosphoinositides
cell signalling
lipids
endosome
retromer
cancer
Areas of expertise My main research interest is in phosphoinositides - dynamic and spatial control of cell signalling.

The membrane phospholipid phosphatidylinositol is the precursor for a family of lipid second-messengers, known collectively as phosphoinositides. Research conducted over the past few decades has established that these lipids, which differ solely in the phosphorylation status of their inositol head group, are crucial components in signalling pathways that lie downstream of cellular stimulation. A major advance in our understanding of phosphoinositide signalling has been the identification of a number of highly conserved modular protein domains that bind various phosphoinositides. To date, a number of distinct, phosphoinositide-binding motifs have been identified and characterised including the ENTH domain, FYVE domain, FERM domain, PH domain and PX domain. Such ‘cut and paste’ modules are found in a diverse array of multidomain proteins and recruit their host protein to specific regions in cells via their interactions with phosphoinositides.