Directory of Experts
Details for Professor Anthony Clarke
| Personal details | |
| Name | Professor Anthony Clarke |
| Job title | Professor of Biochemistry |
| Department | School of Biochemistry University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
| Qualifications | BSc(Sheff), PhD(Bristol) |
| Professional details | |
| Keywords | protein folding chaperone mechanisms protein folding process structure prediction chaperones |
| Areas of expertise | My main research interest is in Protein folding and chaperone mechanisms: One of the fundamental unsolved problems in biological science is how the sequence of a protein dictates its active 3-dimensional structure. If we can find a solution, two fundamental advances would result. Firstly, we would be able to convert DNA sequence data into their encoded 3-D protein structures and, secondly, we could begin to design protein molecules with new structure. Following on from a successful experimental programme which sought to characterise the folding process, we are now using computer-based studies to model this process with the aim of structure prediction. Ongoing experimental programmes seek to identify the molecular mechanisms of chaperones and their influence on protein folding. |