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Details for Dr Karim Malik

Personal details
Name Dr Karim Malik
Job title Reader in Epigenetics
Department School of Cellular and Molecular Medicine University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BSc(Sur), PhD(Cantab)
Professional details
Keywords Wilms' tumour
eukaryotic gene expression
cancer
epigenetics
genetics
non-coding RNA
Areas of expertise Current Research

Cancer epigenetics - We are conducting genome-wide methylation screening using microarrays in order to assess epigenetic lesions in human cancers and the downstream consequences of gene deregulation.

Regulation and cellular functions of the Wilms' tumour suppressor gene, WT1 - Identification of an antisense WT1 promoter has led us to propose novel control mechanisms for eukaryotic gene expression involving antisense RNAs and silencer elements. We also identified a novel WT1 form whose functions are being invesigated.