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Details for Professor Stafford Lightman

Personal details
Name Professor Stafford Lightman
Job title Professor of Medicine
Department Bristol Medical School (THS) University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications MBBChir, PhD(Cantab), FMedSci, FRCP
Professional details
Membership of professional bodies Fellow of United Kingdom Academy of Medical Sciences
Fellow of the Royal College of Physicians
Keywords diurnal and infradian rhythms
stress related disorders
clinical depression
autonomic neuropathy
cushings
addisons
hypothalamic & pituitary disease
Areas of expertise Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.

We are studying the neural pathways in the brain that transduce the CNS response to environmental stress and disease, and measure changes in gene transcription in physiologically relevant areas. We also assess how these pathways effect the efferent limb of the stress reponse by looking at neuroendocrine parameters of hypothalamo-pituitary-adrenal activity (including the pulsatility of corticosterone secretion), autonomic responses(both sympathetic and parasympathetic activity) and immune parameters.

In addition, we are beginning to develop techniques to assess the effects of stress on atheroma formation, and the pathways that are involved.