Mechanisms of Neisseria gonorrhoeae pathogenesis
surface components in virulence
mucosal pathogens and colonisers
mucosal colonisation by commensal neisserial species
Moraxella catarrhalis adhesin UspA1
Areas of expertise
§ Mechanisms of Neisseria gonorrhoeae pathogenesis: studies on the roles of surface components in virulence.
§ Molecular mechanisms of interactions of Neisseria meningitidis and Haemophilus influenzae with human endothelial, epithelial and phagocytic cells.
§ Influence of post-translational modifications of meningococcal pili on their functions
§ Molecular basis of common receptor targeting by Neisseria meningitidis and Haemophilus influenzae and other mucosal pathogens and colonisers
§ Mechanisms of mucosal colonisation by commensal neisserial species.
§ Development of in vitro models that mimic post inflammatory state of host target cells to examine the influence of cellular receptor profiles on increased susceptibility to meningococcal infection.
§ Molecular analysis of the interactions of Neisseria meningitidis and Haemophilus influenzae with polarised human epithelial cells
§ Mechanisms of Neisseria meningitidis targeting of serum factors and intracellular cytoskeletal protein alpha actinin
§ Studies on Structure, function and mechanics of the Moraxella catarrhalis adhesin UspA1