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Details for Dr Keith Brown

Personal details
Name Dr Keith Brown
Job title Reader in Molecular Pathology
Department School of Cellular and Molecular Medicine University of Bristol
Personal web page http://www.bristol.ac.uk/cellmolmed/research/cancer/brown.html
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
email:
Qualifications MA(Cantab), MSc(Birm), PhD(Birm)
Professional details
Keywords molecular genetics
cancer
Wilms' tumour
neuroblastoma
epigenetics
Areas of expertise My research interests are in the molecular genetics of children's cancers, concentrating in particular on two common cancers; Wilms' tumour of the kidney and neuroblastoma, a cancer of the sympathetic nervous system.

§ Epigenetics of childhood cancers:

The aim of this project is to characterize genome-wide DNA methylation changes in clinically important childhood cancers such as Wilms’ tumour and neuroblastoma. This is being achieved by the use of human promoter microarrays, hybridized with tumour DNA enriched for methylated sequences.

§ Novel loci involved in the development of Wilms' tumour

Positional cloning techniques have been used to map and identify the genes present at a novel chromosomal translocation at 7p involved in Wilm functional studies of these genes, as we have already developed for the WT1 gene.

§ Our work is supported by CLIC Sargent