Directory of Experts
Details for Professor Rebecca Sitsapesan
| Personal details | |
| Name | Professor Rebecca Sitsapesan |
| Job title | Research Fellow in Physiology and Pharmacology |
| Department | School of Physiology and Pharmacology University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
| Qualifications | BSc(Aberd), MSc(Leeds), PhD(Strath) |
| Professional details | |
| Membership of professional bodies | Physiological Society American Biophysical Society British Pharmacological Society Working Group on Cardiac Cellular Electrophysiology |
| Keywords | ion-channels intracellular Ca2+-release Two-pore channels (TPCs) TRIC- channels cardiac muscle Ryanodine receptors (RyR) sarcoplasmic reticulum NAADP receptors (NAADPR) |
| Areas of expertise | Intracellular Ion-channel Function Laboratory The release of Ca2+ from intracellular stores is of fundamental importance in cell biology, playing a key role in a wide variety of cellular functions including cardiac and skeletal muscle contraction, fertilisation, cell division and neurotransmitter release. We study the function of intracellularly-located ion-channels involved in the regulation of intracellular Ca2+-release. Ion-channels that we are particularly focusing on include ryanodine receptors (RyR), TRIC-A and TRIC-B channels, nicotinic acid adenine dinucleotide receptors (NAADR), Two-Pore channels (TPCs) and cyclic ADP-ribose receptors (cADPR). Ryanodine receptors (RyR) are an important class of intracellular Ca2+-release channel in cardiac muscle. Cardiac muscle contraction requires release of intracellular Ca2+. Impairments to this release process can be fatal as in inherited arrhythmic diseases and heart failure. |