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Details for Professor Mark Szczelkun

Personal details
Name Professor Mark Szczelkun
Job title Professor of Biochemistry
Department School of Biochemistry University of Bristol
Personal web page http://www.bris.ac.uk/biochemistry/research/mds.html
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BSc(Liv), PhD(Soton)
Professional details
Keywords molecular motors
DNA
genetic processes
protein
ATP hydrolysis
cleavage of DNA
restriction enzymes
repair of DNA
Areas of expertise Mechanism, control and diversity of molecular motors on DNA.

Many genetic processes require the action of large protein machines that act on DNA as a function of ATP hydrolysis. In this way these complexes act as “molecular motors” – they convert chemical energy as ATP into mechanical events. Our lab is interested in how ATP hydrolysis is used to communicate between distant sites on DNA, sites which may be many thousands of base pairs distant. We are currently concentrating on two processes: (1) The cleavage of DNA by the ATP-dependent restriction enzymes; and (2) The repair of DNA damage by the mismatch repair system.