modulation of neurotransmitter release
intracellular signalling mechanisms
release of neurotransmitters
intracellular second messenger pathways
Areas of expertise
Modulation of Neurotransmitter Release
My main interests are the intracellular signalling mechanisms which control release of neurotransmitters from central neurones. More specifically we are focusing on the following questions:
• How do neuromodulators such as angiotensin II affect release of noradrenaline?
• Which intracellular second messenger pathways are responsible for changing the release properties?
• What are the physiological consequences of these effects for synaptic transmission, i.e. the neuronal output from a particular brain area? We are addressing these questions by using a combination of electrophysiological (patch clamp and amperometry), optical (confocal imaging of living brain slice cultures), molecular (viral gene transfer) and pharmacological tools.