Directory of Experts
Details for Dr Suman Peel
| Personal details | |
| Name | Dr Suman Peel |
| Job title | Research Fellow |
| Department | School of Biochemistry University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
| Qualifications | MSc(IISc), PhD(Frankfurt) |
| Professional details | |
| Keywords | Protein aided membrane remodeling and scission cytosolic proteins, escrt-iii |
| Areas of expertise | My research group's interests comprise the following: -Understanding the dynamics of ESCRT-III assembly on membranes using solid supported bilayers and studying the processes in real time using surface sensitive label free and fluorescence detection simultaneously. -Following the structures, composition and direction of growth of ESCRT-III assemblies as they mature on lipid membranes and developing novel probes. We use cryo electron microscopy. -Since ESCRT-III polymer must form through the central pore of a membrane tubule, thereby posing steric hindrance for scission, we wish to study how pore closure followed by scission takes place. To that effect we use membrane nano-tubes drawn from black lipid membranes and measure their ionic permeability as a sensitive read out for pore closure and simultaneously follow the ESCRT-III assembly using fluorescence microscopy with single dye sensitivity. Our ambition is to test the model/hypotheses arising from in vitro data in living systems and in silico. |