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Details for Dr Jonathan Hanley

Personal details
Name Dr Jonathan Hanley
Job title Reader in Molecular Neuroscience
Department School of Biochemistry University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BA(Cantab), PhD(UCLond)
Professional details
Keywords trafficking
dendritic spine
synapse
synaptic transmission
actin cytoskeleton
PICK1
AMPA receptor
Areas of expertise Learning and memory involves changes in the molecular machinery of synapses. AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain, and plasticity at excitatory synapses involves alterations in the number of AMPARs localised at the synaptic plasma membrane, brought about by regulated receptor trafficking.

AMPAR expression at the synaptic plasma membrane is regulated by endocytosis, exocytosis, recycling and lateral diffusion events that contribute to reductions (Long Term Depression, LTD) or increases (Long Term Potentiation, LTP) in synaptic strength. A number of protein interactions with AMPAR subunits have been identified that mediate these trafficking events

The main focus of my lab is investigating how these protein interactions are regulated, and how they influence basic cell biological processes to bring about changes in AMPAR trafficking and hence synaptic strength.