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Details for Professor Graham Collingridge

Personal details
Name Professor Graham Collingridge
Job title Professor of Neuroscience in Anatomy
Professor of Neuroscience in Anatomy
Department School of Physiology, Pharmacology & Neuroscience University of Bristol
School of Physiology, Pharmacology & Neuroscience University of Bristol
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
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Qualifications BSc(Bristol), PhD(Lond), FRS
Professional details
Keywords synaptic mechanisms
synaptic plasticity
mammals
central nervous system
synapses
Areas of expertise The laboratory is interested in synaptic mechanisms and, in particular, synaptic plasticity in the mammalian central nervous system. Synaptic plasticity is the process by which synapses alter their efficiency and this property is used by the nervous system to store information. Synaptic plasticity is therefore a fundamental property of the brain involved in the development of the nervous system, learning & memory and other cognitive processes. Dysfunction of synaptic plastic processes is believed to be involved in various psychiatric and neurological disorders, including epilepsy and ischaemic brain injury.

We are particularly interested in the phenomena of long-term potentiation (LTP) and long-term depression (LTD), which are forms of synaptic plasticity exhibited by many different classes of synapse in the brain.