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Details for Professor Craig McArdle

Personal details
Name Professor Craig McArdle
Job title Professor of Molecular Pharmacology
Department Bristol Medical School (THS) University of Bristol
Personal web page
Contact details This expert can be contacted via the University of Bristol Public Relations Office.

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work+44 (0)117 331 8092
Qualifications BSc, PhD(CNAA)
Professional details
Membership of professional bodies Bristish Pharmacological Society, Society for Endocrinology, Endocrine Society
Keywords cell signalling
G-protein coupled receptor signalling
G-protein coupled receptor trafficking
gonadotrophin-releasing hormone signalling
ERK signalling
Areas of expertise My research interests are in cell signalling and reproductive endocrinology and most of my group's work focuses on the hypothalamic decapeptide GnRH, that acts via G-protein coupled receptors on pituitary gonadotrophs to mediate control of reproduction by the CNS. Type I mammalian GnRH receptors are unique in that they lack the C-terminal tails found in other G-protein coupled receptors. Much of our recent work addresses the functional relevance of this distinction, placing emphasis on receptor desensitisation and internalisation as well as ERK activation. Most recent work exploits image-based readouts (e.g. fluorescent reporters) for activity of signalling proteins using semi-automated fluorescence microscopy (high content analysis). We are combining this with mathematical modeling to explore molecular mechanisms by which cells decode hormone pulse frequency.
Media experience none