I am a committee member of the British Society for Haemostasis and Thrombosis, a Principal Editor for Platelets, on the Editorial Advisory Board for the Journal of Thrombosis and Haemostasis and a full Editorial Board member for the Journal of Biological Chemistry.
primary haemostatic system
pathological development of thrombosis
cell biology of platelets
Areas of expertise
Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.
Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.