Directory of Experts
Details for Dr Jonathan Wakerley
| Personal details | |
| Name | Dr Jonathan Wakerley |
| Job title | Visiting Fellow |
| Department | Centre for Comparative and Clinical Anatomy University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
| Qualifications | BSc(Nott), PhD(Bristol) |
| Professional details | |
| Keywords | hypothalamic oxytocinergic neurones oxytocin oxytocinergic neurones birth lactation limbic system hypothalamic neuroepeptides steroids |
| Areas of expertise | My research interests are in the following areas: Mechanisms controlling synchronous firing of hypothalamic oxytocinergic neurones I am interested in the autoregulatory actions of dendritically-released oxytocin in controlling synaptic inputs to oxytocinergic neurones during birth and lactation, and the importance of afferent modulation in determining burst firing and synchronicity. I am also interested in the adaptations shown by oxytocinergic neurones at the end of pregnancy that promote synchronous bursting activity, and the role of steroids in regulating these adaptations. Central actions of peptides in the limbic system Hypothalamic neuroepeptides such as oxytocin and corticoptrophin act as neuromodulators in the limbic system and are involved in social, maternal and stress-related behaviour. I am interested in the cellular mechanisms by which neuropeptides exert their effects, and how these mechanisms are modulated by the genomic and membrane actions of steroids (including neurosteroids). Educational research project: the role of Intercalation in Medical Education |