thymic development of natural T regulatory cells
peripheral development of inducible T regulatory cell types
the suppressive effect of T regulatory cells
Areas of expertise
The role of CTLA-4 in immune regulation.
CTLA-4 is a co-stimulatory molecule, similar to CD28. Unlike CD28 however, CTLA-4 is generally thought to inhibit T cell activation rather than promote it. Its expression on T regulatory cells and the rapid onset of autoimmune disease in the absence of CTLA-4 suggest this molecule plays an important role in immune regulation. The effect of CTLA-4 on individual T cell subsets and its mechanism of action remain debated. Our main aims are to better understand the role of CTLA-4 in;
-Thymic development of natural T regulatory cells -Peripheral development of inducible T regulatory cell types -The suppressive effect of T regulatory cells