Directory of Experts
Details for Dr Johan Verhagen
| Personal details | |||
| Name | Dr Johan Verhagen | ||
| Job title | Research Associate |
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| Department | School of Cellular and Molecular Medicine University of Bristol |
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| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 928 7777 email: public-relations@bristol.ac.uk |
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| Qualifications | MSc(Amst), PhD(Zuer) | ||
| Professional details | |||
| Keywords | thymic development of natural T regulatory cells peripheral development of inducible T regulatory cell types the suppressive effect of T regulatory cells |
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| Areas of expertise | The role of CTLA-4 in immune regulation. CTLA-4 is a co-stimulatory molecule, similar to CD28. Unlike CD28 however, CTLA-4 is generally thought to inhibit T cell activation rather than promote it. Its expression on T regulatory cells and the rapid onset of autoimmune disease in the absence of CTLA-4 suggest this molecule plays an important role in immune regulation. The effect of CTLA-4 on individual T cell subsets and its mechanism of action remain debated. Our main aims are to better understand the role of CTLA-4 in; -Thymic development of natural T regulatory cells -Peripheral development of inducible T regulatory cell types -The suppressive effect of T regulatory cells |
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