Potential involvement and target identification of HuR/ELAVL1 in age-related ocular pathologies – Back to the origin

20 July 2020, 4.00 PM - 20 July 2020, 5.00 PM

Prof Marialaura Amadio (University of Pavia)

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Hosted by neuroEYEscience

In the last decades, the post-transcriptional control of gene expression has become an area of intense investigation, delineating a complex scenario where several factors (e.g. RNA-binding proteins, coding and non-coding RNAs) orchestrate the fate of a given transcript. An intriguing hypothesis suggests that loss of RNA homeostasis is a central feature of many pathological states, including eye diseases. In the 25-year anniversary of the elav (embryonic lethal, abnormal visual system) gene discovery in the Drosophila melanogaster, the mammalian ELAV-like family confirms its leading role in controlling the RNA metabolism (from splicing to translation) of genes with a key function in many physio-pathological contexts. Some relevant findings suggest the involvement of the HuR/ELAV-like1 member and its potential as a therapeutic target in age-related ocular pathologies.

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