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Professor Julian Paton

Impact

I have given a number of public lectures on my research and on the clinical problem of high blood pressure (‘Pumping up the Pressure! Why high blood pressure is bad for you’, and more general lectures on ‘Revealing Physiology’ and ‘Fizziology is Phun’. These have been to school pupils within schools as well as to the general public. I have been invited to make these lectures in the UK, Brazil and the United States of America. Some of the lectures are listed below:

 

  • 2000-2010 University Open Day lectures, University of Bristol
  • 2004, Lecture, Taunton School, Taunton, Somerset
  • 2004 L. Floyd Clarke Memorial Lecturer, Univ. Wyoming, Laramie, USA
  • 2005, Public Lecture, Physiological Society-FEPS, University of Bristol, Bristol.
  • 2006, Public Lecture, Brazilian Physiological Society, Ribeirao-Preto, Brazil.
  • 2006, University of the Third Age, Bath
  • 2006 Keynote Speaker, Research Appreciation Day, Univ. North Texas, Dallas, Texas, USA.
  • 2007, Seminars to VIth formers Taunton School, Taunton, Somerset
  • 2009 Key Note Speaker, Inaugural Undergraduate Physiological Symposium, University of Oxford

Research findings

  • 1995-1996: Invention of a “tour de force” integrative physiological in situ working heart- brainstem preparation. This allowed studies we could not have done previously.
  • 1998-2002: In collaboration with Professor Sergey Kasparov, we revealed that brainstem actions of angiotensin II, a peptide associated with hypertension, were mediated by liberation of nitric oxide from the endothelium leading to a novel form of brain signalling: vascular-neuronal signalling.
  • 2003: We provided unequivocal evidence that vascular-neuronal signalling in the brainstem contributed to high blood pressure levels in an animal model of hypertension.
  • 2006-present: Discovery that brainstem pacemaker activity was essential for gasping. This and other work dives our mathematical modelling which contributes to the Human Physiome Project.
  • 2007- present: In collaboration with Professor David Murphy, we identified unique genes within brain regions regulating arterial pressure thereby providing unique clues as to those that may generate neurogenic hypertension.
  • 2007: We discovered that the brainstem vasculature was inflamed in the hypertensive brain.
  • 2007: In collaboration with Professors Jeff Smith (NINDS, NIH) and Ilya Rybak (Drexel University), we revealed the precise compartments of the brainstem for generation of distinct respiratory patterns and the conditions and mechanisms for expression of these different rhythms.

2009: In collaboration with Dr Andrew Allen (Melbourne University) and Dr Anthony Pickering, we discovered that enhanced sympathetic activity precedes the onset of hypertension and is dependent on exacerbated modulation by the brainstem respiratory pattern generator.