Understanding the processes that dictate the distribution, maintenance and dynamics of neurotransmitter receptors is of fundamental importance to the molecular basis of fast excitatory transmission, synaptic plasticity and brain function.
The Henley lab is interested in the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from synapses under normal, stimulated and disease conditions. Receptors share common biosynthetic and endocytic pathways but important specific differences allow selective regulation.
Increased understanding of the mechanisms of these processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and ...
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