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Dr Maria Usowicz

Dr Maria Usowicz

Dr Maria Usowicz
BSc, PhD

Senior Lecturer - following retirement

Area of research

Neuronal function in the cerebellum; Down's syndrome

School of Physiology, Pharmacology & Neu,
Biomedical Sciences Building, University Walk BS8 1TD
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Research summary

1. Voltage-gated calcium channels in the brain

P-type calcium channels were first described in the cerebellar Purkinje cell, but are thought to be widely distributed throughout the brain and to control many diverse fundamental processes. Mutations in the CACNA1A gene that encodes the main subunit (Cav2.1, alpha 1A) may underly various neurological disorders, such as different forms of migraine and ataxia.  We are investigating how the functional and molecular properties of P-type channels vary between different types of brain neurons and during neuronal maturation.

Purkinje cell 2

patch-clamp recording from a Purkinje cell in a slice of cerebellum during drug application from a macropipette

Patch-clamp ...

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Selected publications

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Recent publications

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View complete publications list in the University of Bristol publications system

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