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Dr Domingo Tortonese

Dr Domingo Tortonese

Dr Domingo Tortonese
D.V.M., Dr.Vet.Sci.(LaPlata), Ph.D.(W.Virginia)

Senior Lecturer in Anatomy

Office 3.48 S. Street
Centre for Applied Anatomy,
Southwell Street, Bristol BS2 8EJ
(See a map)

Tel. +44 (0) 117 928 8332

Research summary

My research focuses on the neuroendocrine regulation of fertility.

The specific aim is to identify the signal transduction pathways and the neural, cellular and molecular mechanisms underlying the control of gonadotrophin releasing hormone (GnRH) and gonadotrophin secretion during naturally occurring temporal changes in fertility.

To this end, my team has developed two complementary lines of research: on one hand, to investigate the regulation of GnRH neuronal networks within the hypothalamus, and, on the other, the paracrine interactions within the pituitary gland that may modulate the response of gonadotroph cells to GnRH stimulation. The link between these two lines of research ...

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I intend to continue our investigations into the regulation of the neuronal networks that govern reproductive function, i.e. GnRH neurones, and the intercellular communications within the pituitary gland that modulate the response of gonadotrophs to GnRH stimulation. Our immediate goals are (1) to study the signal transduction pathways underlying the effects of prolactin on GnRH neuronal activity, using neuronal cell lines and viral transfections, and (2) to elucidate the paracrine mechanisms within the pituitary that modulate gonadotrophin secretion, using molecular strategies in pituitary cell lines and primary cultures from photoperiodic species.

It is also my intention to continue and ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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