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Professor Seth Love Neuropathology of Alzheimer's disease, cerebral amyloid angiopathy, prion disease, stroke, and other disorders; research and clinical practice Full contact details |
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Projects - Diseases - Processes - Funding - Collaborations - Teaching - Group members - Publications & further information
Research
Over the past ten years much of Professor Love's research has focused on the pathogenesis of nerve cell damage and death in neurological disease - Alzheimer's disease in particular. Together with Dr Patrick Kehoe, he now jointly heads the Dementia Research Group, a part of the Institute of Clinical Neurosciences (for which he is Director), and the Department of Clinical Science at North Bristol (for which he is Deputy Head of Department).
A hallmark of Alzheimer's disease (AD) is the accumulation within the brain of plaques - large clumps of a protein known as Abeta (Abeta). There is now a great deal of evidence that the accumulation of Abeta and the secondary damage this causes to brain tissue is central to the development of AD.
The Dementia Research Group has a multidisciplinary approach to the investigation of AD pathology. This involves the use of molecular genetic, molecular biological, cell culture in conjunction with histological and immunohistochemical approaches which are largely underpinned by tissue from the South West Dementia Brain Bank (SWDBB). Recent and current research has concerned the metabolism and clearance of Abeta, the causes and complications of accumulation of A? in the tissue and walls of blood vessels within the brain, abnormalities of the cerebral extracellular matrix (the gel-like substance that surrounds and supports the brain cells) in AD, and the reasons why patients lose the specialised junctions (synapses) between their nerve cells.
For more details see Dementia Research Group website.
The Dementia Research Group is also part of the Bristol Dementia Consortium. This consortium includes two other University of Bristol groups: Dr Andrea Tales' Mild Cognitive Impairment Group and Drs Dave Dawbarn and Shelley Allen 's Molecular Neurobiology Laboratory at the Laboratories for Integrative Neuroscience and Endocrinology.
The Bristol Dementia Consortium was one of the founding members of what is now the Bristol and Bath Alzheimer's Research Trust (ART) Network Centre , which also includes members from:
- University of Bristol :
- University West of England :
- University of Bath :
- effects of and genetic risk factors for cerebral amyloid angiopathy
- mechanisms by which different isoforms of apoE influence chronic degenerative and acute neurological diseases
- extracellular matrix destruction in Alzheimer's disease
- oxidative stress and damage to the perineuronal net in scrapie
- assessment of risk of embolic dissemination of brain tissue during captive bolt stunning and slaughter of cattle and sheep
- transforming growth factor b in neonatal post-haemorrhagic ventricular dilation
- determinants of remyelination in Multiple Sclerosis
- detection of markers of chemosensitivity and radiosensitivity in glial tumours
Further studies of the pathogenesis and genetic risk factors for cerebral amyloid angiopathy, and of matrix metalloproteinases and degradation of the extracellular matrix in Alzheimer's disease and prion disease
Alzheimer's disease, cerebral amyloid angiopathy, stroke, prion disease, neonatal post-haemorrhagic hydrocephalus, glial tumours
Mechanisms of neurodegeneration, oxidative stress, hydrocephalus, chemosensitivity, radiosensitivity
Projects - Diseases - Processes - Funding - Collaborations - Teaching - Group members - Publications & further information
Grants and funding
The research is supported by the MRC, Alzheimer's Research Trust, BRACE, Action Research, the Food Standards Agency and some smaller local charities.Collaborations
- Dementia Research Group (Professor Wilcock, Dr Patrick Kehoe)
- Academic Neurology (Professor Scolding)
- Neonatal Neurology (Professor Whitelaw, Marianne Thoresen)
- Department of Clinical Veterinary Science (Haluk Anil)
- Departments of Clinical Genetics and Oncology (Linda Tyfield, Kirsten Hopkins)
Teaching
Teaching of Neuropathology to Y2 and Y5 medical students; contributions to several undergraduate and postgraduate neuroscience courses; co-organizer of Wye College Neuropathology SymposiaPublications, recommended reading and further information
Recent selected publications
Love S, Miners JS, Palmer J, Chalmers K, Kehoe PG.
Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy.
Frontiers in Bioscience. (In Press)
Chalmers KA, Love S
Phosphorylated Smad 2/3 co-localizes with phospho-tau inclusions in Pick's disease, progressive supranuclear palsy and corticobasal degenerations but not with ?-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.
Journal of Neuropathol Experimental Neurology . (In Press)
Gray E, Thomas TL, Betmouni S, Scolding N, Love S.
Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis.
Brain Pathology (In Press)
Chalmers KA, Love S . (2007)
Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.
J Neuropathol Exp Neurol. 2007 Feb; 66 (2):158-67.
Miners JS, Verbeek M, Olde Rikkert M, Kehoe PG, Love S (2007)
Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid .
Journal of Neuroscience Methods. Aug 25; (EPub ahead of print)
Books:
Love S.
Neuropathology of Ageing.
In: Principles and Practice of Geriatric Medicine, 3rd Edition. Edited by MSJ
Pathy. John Wiley & Sons, Chichester, Vol 1, pp 77-89, 1998.
Love S, Hilton DA.
Transplantation in the CNS.
In: Current Topics in Pathology, Volume 92. Transplantation Pathology. Edited
by CL Berry. Springer-Verlag, pp 181-213, 1998.
Love S, Wiley CA.
Viral infections.
In: Greenfield's Neuropathology. Vol 2. 7th Edition. Edited by DI Graham and
PL Lantos. Arnold, Vol 2. pp.1-105, 2002.
Love S.
Autopsy approach to infections of the CNS.
In: Current Topics in Pathology. Neuropathology. Edited by S Love. Springer-Verlag,
2001.
Love S.
Trigeminal neuralgia.
In: Elsevier's Encyclopedia of Neuroscience. 3rd Edition. Edited by G Adelman
and BH Smith. Elsevier, 2004.
Neuropathology.
Edited by D Ellison and S Love. Mosby International Ltd, London. 1st edition
1998. 2nd edition 2004.
Current Topics in Pathology. Neuropathology.
Edited by S Love.
Springer-Verlag,
2001.
More details of my research can be found on the Dementia Research Group website.
Projects - Diseases - Processes - Funding - Collaborations - Teaching - Group members - Publications & further information