16 November 2005
New ways to alleviate debilitating pain are being investigated in the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology.
In addition, aspects of asthma relating to sensitisation of sensory neurons are currently untreatable. In a collaboration with Christine Nassenstein and Armin Braun, at the University of Hanover, the group have shown that TrkAD5 controls this aspect of asthma. Thus TrkAD5 is unique in that it is the only compound which has been able to do this.
This binding domain is covered by four University patents. The protein, renamed as REN1820, has been out-licensed to a pharmaceutical company for clinical application. In collaboration with a number of groups worldwide the Dawbarn/Allen group have shown that this protein is effective in models of interstitial cystitis, pancreatitis, inflammatory pain, neuropathic pain and asthma. The protein is now at the stage of technology transfer for large-scale production to GMP (good manufacturing practice). It is envisaged that REN1820 will initially be used for the treatment of interstitial cystitis by subcutaneous injection.