"Have I been here before?"
Press release issued: 7 June 2007
"Have I been here before?" In today's fast-moving world of look-alike hotel rooms and comparable corridors, it can take a bit of thinking to answer this simple question. University of Bristol neuroscientists working with colleagues at the Massachusetts Institute of Technology (MIT) report in the June 7 early online edition of Science that they have identified a neuronal mechanism that our brains may use to rapidly distinguish similar, yet distinct places.
The work could lead to treatments for memory-related disorders, as well as for the confusion and disorientation that plague elderly individuals who have trouble distinguishing between separate but similar places and experiences.
Forming memories of places and contexts in which episodes occur engages a part of the brain called the hippocampus. The laboratory of Nobel Laureate, Susumu Tonegawa, Picower Professor of Biology and Neuroscience at MIT, has been exploring how each of the three hippocampal subregions-the dentate gyrus, CA1 and CA3-contribute uniquely to different aspects of learning and memory. In the current study, co-authors Matthew Jones, Research Councils UK (RCUK) Academic Fellow in the Department of Physiology at the University of Bristol and Dr Thomas McHugh, a Picower Institute research scientist, have revealed that the learning in the dentate gyrus is crucial in rapidly recognizing and amplifying the small differences that make each place unique.
Dr Jones, commenting on the paper, said: "We constantly make split-second decisions about how best to behave at a given place and time. To achieve this, our nervous system must employ highly efficient ways of rapidly recognising and learning important changes in our environment.
"This paper demonstrates that a particular protein signalling molecule (the NMDA receptor) in a particular network of brain neurons (the dentate granule cells of the hippocampus) is essential for these rapid discrimination processes, hopefully paving the way for therapies targeting learning and behavioural disorders."
Professor Tonegawa, a frequent world traveler, describing his own occasional experience of finding the airport in a new city uncannily familiar, added: "This occurs because of the similarity of the modules-gates, chairs, ticket counters-that define the context of an airport. It is only by seeking out unique cues that the specific airport can be identified."
Researchers believe that a set of neurons called 'place cells' fire to provide a sort of blueprint for any new space we encounter. The next time we see the space, those same neurons fire. Thus we know when we've been somewhere before and don't have to relearn our way around familiar turf. But similar spaces may activate overlapping neuronal blueprints, leaving room for confusion if the neurons are not fine-tuned.
In this study, the researchers used a line of genetically altered mice to pinpoint how the dentate gyrus contributes to the kind of pattern separation involved in identifying new and old spaces. Whilst the mice behaved normally in most situations, they became confused when required to discriminate between different spaces. This may model the difficulties in forming distinct memories for similar but distinct places and experiences that afflicts some elderly individuals.
In addition to Dr Matthew Jones, Professor Susumu Tonegawa and Dr Thomas McHugh, authors include Matthew Wilson, Picower Scholar and Professor; and colleagues from the University of California at Los Angeles and Beth Israel Deaconess Medical Center in Boston.
This work was supported by the National Institute for Mental Health and the National Institutes of Health.
Further informationThe paper: Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network, Thomas J. McHugh, Matthew W. Jones, Jennifer J. Quinn, Nina Balthasar, Roberto Coppari, Joel K. Elmquist, Bradford B. Lowell, Michael S. Fanselow, Matthew A. Wilson and Susumu Tonegawa, Science Express 7 Jun 2007.
Dr Matthew Jones and Dr Nina Balthasar are both RCUK Academic Fellows in the Department of Physiology at Bristol University. Dr Matthew Jones carried out research for the paper while he was a postdoc at MIT, with collaborators from Harvard Medical School (including Nina Balthasar who was a postdoc there at the time) and UCLA.
Follow-up work will continue in Dr Jones’ lab at Bristol University with fellow members of Bristol’s MRC Centre for Synaptic Plasticity.
Professor Susumu Tonegawa won the Nobel Prize for Physiology or Medicine in 1987 for “his discovery of the genetic principle for generation of antibody diversity.” Although he won the Nobel Prize for his work in immunology, Professor Tonegawa is a molecular biologist by training. In his later years, he has turned his attention to the molecular and cellular basis of memory formation.