Chemists create 'assembly-line' for organic molecules
10 September 2014
Scientists at the University of Bristol have developed a process where reagents are added to a growing carbon chain with extraordinary high fidelity and precise orientation, thereby controlling the conformation of the molecule so that it adopts a helical or linear shape. The process can be likened to a molecular assembly line.
Nature has evolved highly sophisticated machinery for organic synthesis. One of the most beautiful examples is its machinery for the synthesis of polyketides, a very important class of molecules due to their broad spectrum of biological activities (for example antibiotic, antitumor, antifungal, antiparasitic).
In this process, a simple thioester (small building block) is passed from one enzyme domain to another, growing as it does so until the target molecule is formed. The process resembles a molecular assembly line.
The Bristol researchers sought to emulate nature in the construction of their own molecular assembly line through a related iterative process. But iterative processes are very challenging as each iteration must occur with >99.5 per cent efficiency, and >99.5 per cent stereocontrol otherwise mixtures would result.
In a paper published in the journal Nature today, the scientists report a reagent which reacts with their small building blocks (boronic esters) with exceptionally high fidelity and stereocontrol.
Through repeated iteration they have converted a simple building block into a complex molecule (a carbon chain with ten contiguous methyl groups) with remarkably high precision over its length, its stereochemistry and therefore its shape.
Different stereoisomers were targeted and it was found that they adopted different shapes (helical/linear) according to their stereochemistry.
This work should now enable molecules with predictable shape to be rationally designed and created which could have an impact in all areas of molecular sciences where bespoke molecules are required.
'Assembly-line synthesis of organic molecules with tailored shapes' by Matthew Burns, Stéphanie Essafi, Jessica R. Bame, Stephanie P. Bull, Matthew P. Webster, Sébastien Balieu, James W. Dale, Craig P. Butts, Jeremy N. Harvey and Varinder K. Aggarwal in Nature