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How human sperm really swim: research challenges centuries-old assumption

The sperm tail moves very rapidly in 3D, not from side-to-side in 2D as it was believed. polymaths-lab.com

Sperm tail moves like a precessing spinning top that cancels out the one-sided swimming stroke in an ingenious corkscrew motion: Symmetry is achieved through asymmetry, enabling human sperm to swim forwards. polymaths-lab.com

Press release issued: 31 July 2020

A breakthrough in fertility science by researchers from Bristol and Mexico has shattered the universally accepted view of how sperm ‘swim’.

More than three hundred years after Antonie van Leeuwenhoek used one of the earliest microscopes to describe human sperm as having a “tail, which, when swimming, lashes with a snakelike movement, like eels in water”, scientists have revealed this is an optical illusion.

Using state-of-the-art 3D microscopy and mathematics, Dr Hermes Gadelha from the University of Bristol, Dr Gabriel Corkidi and Dr Alberto Darszon from the Universidad Nacional Autonoma de Mexico, have pioneered the reconstruction of the true movement of the sperm tail in 3D.

Using a high-speed camera capable of recording over 55,000 frames in one second, and a microscope stage with a piezoelectric device to move the sample up and down at an incredibly high rate, they were able to scan the sperm swimming freely in 3D.

The ground-breaking study, published in the journal Science Advances, reveals the sperm tail is in fact wonky and only wiggles on one side. While this should mean the sperm’s one-sided stroke would have it swimming in circles, sperm have found a clever way to adapt and swim forwards.

“Human sperm figured out if they roll as they swim, much like playful otters corkscrewing through water, their one-sided stoke would average itself out, and they would swim forwards,” said Dr Gadelha, head of the Polymaths Laboratory at Bristol’s Department of Engineering Mathematics and an expert in the mathematics of fertility.

“The sperms’ rapid and highly synchronised spinning causes an illusion when seen from above with 2D microscopes - the tail appears to have a side-to-side symmetric movement, “like eels in water”, as described by Leeuwenhoek in the 17th century.

“However, our discovery shows sperm have developed a swimming technique to compensate for their lop-sidedness and in doing so have ingeniously solved a mathematical puzzle at a microscopic scale: by creating symmetry out of asymmetry,” said Dr Gadelha.

“The otter-like spinning of human sperm is however complex: the sperm head spins at the same time that the sperm tail rotates around the swimming direction. This is known in physics as precession, much like when the orbits of Earth and Mars precess around the sun.”

Computer-assisted semen analysis systems in use today, both in clinics and for research, still use 2D views to look at sperm movement. Therefore, like Leeuwenhoek’s first microscope, they are still prone to this illusion of symmetry while assessing semen quality. This discovery, with its novel use of 3D microscope technology combined with mathematics, may provide fresh hope for unlocking the secrets of human reproduction.

“With over half of infertility caused by male factors, understanding the human sperm tail is fundamental to developing future diagnostic tools to identify unhealthy sperm,” adds Dr Gadelha, whose work has previously revealed the biomechanics of sperm bendiness and the precise rhythmic tendencies that characterise how a sperm moves forward.

Dr Corkidi and Dr Darszon pioneered the 3D microscopy for sperm swimming.

“This was an incredible surprise, and we believe our state-of the-art 3D microscope will unveil many more hidden secrets in nature. One day this technology will become available to clinical centres,” said Dr Corkidi.

“This discovery will revolutionize our understanding of sperm motility and its impact on natural fertilization. So little is known about the intricate environment inside the female reproductive tract and how sperm swimming impinge on fertilization. These new tools open our eyes to the amazing capabilities sperm have,” said Dr Darszon.

Paper

'Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering' by Hermes Adelha et al in Science Advances.

Further information

The Polymaths Lab at the University of Bristol

The Polymaths Lab is based at the Department of Engineering Mathematics and nested at Soft-Robotics at Bristol Robotics Laboratory. 

The laboratory focuses on novel questions and unexplained phenomena in a broad range of physical systems found in nature. Inspired by engineering and mathematical problems found in biology, industry and the arts, and using a combination of analytical derivations, numerical computations and empirical investigations, research areas range from animal and human fertilisation, swimming of microorganisms - especially human spermatozoa and bacterial swimming, cancer mechanics, molecular-motor dynamics, fluid-structure interactions of intelligent structures, plus synthetic bio-inspired propellers and swimmers. 

Interdisciplinarity is at the heart of the poly-disciplinary research, and group members work within a worldwide network which spans an umbrella of universities and industrial partners across 12 countries, from oil and food industries, to fertility clinics and livestock companies.

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