Dr Andrew Doherty

Summary

My research work has been in the pharmacology and trafficking of metabotropic glutamate receptors. Working with Profs Graham Collingridge and David Jane, we were testing phenylglycine derivatives for agonist/antagonists that could distinguish between the group I mGlu receptors. We were also looking at the mechanism of internalisation of mGlu1 receptors.

Biography

I am the Senior Scientific Officer for the MRC Centre for Synaptic Plasticity. This position has multiple roles within it. I am responsible for the management and maintenance of large, multi-user equipment - such as confocal microscopes and multi-photon microscopes, as well as the training on those systems. I am further responsible for the the development and maintenance of the web site for the MRC Centre for Synaptic Plasticity and for the development of the web site for the School of Physiology and Pharmacology.

I am also a teaching Fellow within the School of Physiology and Pharmacology, teaching on level 2 courses on the Principles of Pharmacology as well as on the BSc in Neuroscince (CNS neuroanatomy and level 1 Techniques in Neuroscience).

In addition, I am the Deputy Biological Safety Officer for the School of Physiology and Pharmacology, with responsibility for ensuring that work using dangerous pathogens and genetically modified organisms is properly licensed and carried out withing the relevant regulations.

Activities / Findings

• CHPG is a mGlu5 selective agonist
• mGlu1 receptor internalisation is induced by glutamate

Teaching

B.Sc. in Neuroscience

Techniques in Neuroscience - Level 1

CNS neuroanatomy

 

B.Sc in Pharmacology

Principles of Pharmacology - level 2

Keywords

• Glutamate
• synaptic plastcity

Skills

• neurodegenerative disease

Processes and functions

• synaptic plasticity

Methodologies

• imaging technology
• molecular biology
• immunotechnology

Memberships

Organisations

School of Physiology and Pharmacology

MRC Centre for Synaptic Plasticity

Other sites

• Neuroscience
• Synaptic

Research Areas

• Molecular Neuroscience
• Neuronal Plasticity
• Learning and Memory
• Cell signalling

Research Themes

• Neuroscience

Selected publications

• Peineau, S, Bradley, C, Taghibiglou, C, Doherty, A, Bortolotto, Z, Wang, Y & Collingridge, G 2008, ‘The role of GSK-3 in synaptic plasticity’. British Journal of Pharmacology, vol 153., pp. S428 - s437
• Doherty, A, Coutinho, V, Collingridge, G & Henley, J 1999, ‘Rapid internalisation and surface expression of a functional, fluorescently-tagged G-protein-coupled glutamate receptor’. Biochemical Journal, vol 341., pp. 415 - 422
• Doherty, A, Palmer, M, Henley, J, Collingridge, G & Jane, D 1997, ‘(RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) activates mGlu⁵, but not mGlu¹, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus’. Neuropharmacology, vol 36., pp. 265 - 267

Read more >

Recent publications

• Nicolas, CSC, Amici, M, Bortolotto, ZA, Doherty, AJ, Csaba, Z, Dournaud, P, Gressens, P, Collingridge, GL & Peineau, SAJ 2013, ‘The role of JAK-STAT signalling within the CNS’. JAK/STAT., pp. 1-10
• Amici, M, Doherty, A, Jo, J, Jane, D, Cho, K, Collingridge, G & Dargan, S 2009, ‘Neuronal calcium sensors and synaptic plasticity’. Biochem Soc Trans, vol 37., pp. 1359 - 1363
• Dargan, S, Clarke, V, Alushin, G, Sherwood, J, Nistico, R, Bortolotto, Z, Ogden, A, Bleakman, D, Doherty, A, Lodge, D, Mayer, M, Fitzjohn, S, Jane, D & Collingridge, G 2009, ‘ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function’. Neuropharmacology, vol 56., pp. 121 - 130
• Doherty, A, Collingridge, G & Fitzjohn, S 2009, ‘GABA-B receptor function’. in: Larry R Squire (eds) Encyclopedia of Neuroscience. Academic Press, pp. 471 - 475
• Doherty, A, Fitzjohn, S & Collingridge, G 2009, ‘Long-term potentiation (LTP): NMDA receptor role’. in: Larry R Squire (eds) Encyclopedia of Neuroscience. Academic Press, pp. 555 - 560
• Piccinin, S, Thuault, S, Doherty, A, Brown, J, Randall, A, Davies, C, Bortolotto, Z & Collingridge, G 2008, ‘The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs’. Neuropharmacology, vol 55(4)., pp. 459 - 463
• Fitzjohn, S, Doherty, A & Collingridge, G 2008, ‘The use of the hippocampal slice preparation in the study of Alzheimer's disease’. European Journal of Pharmacology, vol 585 (1)., pp. 50 - 59

View complete publications list in the University of Bristol publications system

Networks & contacts

• members of the MRC Centre for synaptic plasticity
• other peeps