Professor Andy Randall

Research summary

Our group is interested in the neurophysiological changes associated with neurological diseases, in particular Alzheimer’s disease and schizophrenia. Experimentally the major part of our work involves a host of electrophysiological methods stretching from single channel recording, through cellular neurophysiology in vitro, to tetrode recordings of neuronal activity in vivo. We also utilise a number of optical methods including single cell imaging and photo-activated ion channels such as Channelrhodopsins.

We work in close association with the pharmaceutical industry who fund much of the work in the lab. We also have a host of collaborations within Bristol the research community.

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Selected publications

• Nowacki, J, Osinga, H, Brown, J, Randall, A & Tsaneva-Atanasova, K 2011, ‘A unified model of CA1/3 pyramidal cells: An investigation into excitability’. Prog Biophys Mol Biol, vol 105(1-2)., pp. 34 - 48
• Randall, A, Witton, J, Booth, C, Hynes-Allen, A & Brown, J 2010, ‘The functional neurophysiology of the amyloid precursor protein (APP) processing pathway’. Neuropharmacology, vol 59., pp. 243 - 267

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Recent publications

• Brown, J, Hainsworth, AH, Stefani, A & Randall, AD 2013, ‘Whole-cell patch-clamp recording of voltage-sensitive ca(2+) channel currents in single cells: heterologous expression systems and neurones’. Methods in molecular biology (Clifton, N.J.), vol 937., pp. 123-48
• Petrovic, MM, Nowacki, J, Olivo, V, Tsaneva-Atanasova, K, Randall, AD & Mellor, JR 2012, ‘Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus’. PLoS ONE, vol 7., pp. 1 - 10

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View complete publications list in the University of Bristol publications system