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Dr Chrissy Hammond
Dr Chrissy Hammond
Area of research
Regulation of cartilage and bone homeostasis in development and in disease
My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.
The lab is currently mapping and characterising a number of mutant genes, which I identified in a forward genetic screen while in the Schulte-Merker at the Hubrecht Institute in the Netherlands. All of the mutant fish generate too much bone and show loss of cartilage matrix integrity and changes to joint structure, all of which are hallmarks of osteoarthritis.
Activities / Findings
- Two populations of osteoblasts (bone forming cells) respond to different levels of Hedgehog signalling Read more >
- E, [VE, AM, [VV, HJ, [VK, Styrkarsdottir, U, Zhu, Y, Meulenbelt, I, Lories, R, Karassa, F, Tylzanowski, P, Bos, S, Consortium, TA, Akune, , Arden, N, Carr, A, Chapman, K, Cupples, L, Dai, J, Deloukas, P, Doherty, M, Doherty, S, Engstrom, G, Gonzalez, A, Halldorsson, B, Hammond, C, Hart, D, Helgadottir, H, Hofman, A, Ikegawa, S, Ingvarsson, T, Jiang, Q, Jonsson, H, Kaprio, J, Kawaguchi, H, Kisand, K, Kloppenburg, M, Kujala, U, Lohmander, L, Loughlin, J, Luyten, F, Mabuchi, A, McCaskie, A, Nakajima, M, Nilsson, P, Nishida, N, Ollier, W, Panoutsopoulou, K, Putte, Tvd, Ralston, S, Rivadeneira, F, Saarela, J, Schulte-Merker, S, Shi, D, Slagboom, P, Sudo, A, Tamm, A, Tamm, A, Thorleifsson, G, Thorsteinsdottir, U, Tsezou, A, Wallis, G, Wilkinson, J, Yoshimura, N, Zeggini, E, Zhai, G, Zhang, F, Jonsdottir, I, Uitterlinden, A, Felson, D, Meurs, Jv, Stefansson, K, Ioannidis, J & Spector, T 2011, Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the Rheumatic Diseases, vol 70 (2)., pp. 349 - 355
- Spoorendonk, K, Hammond, C, Huitema, L, Vanoevelen, J & Schulte-merker, S 2010, Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Journal of Applied Ichthyology, vol 26., pp. 219 - 224
Read more >
- Hayes, AJ, Reynolds, S, Nowell, MA, Meakin, LB, Habicher, J, Ledin, J, Bashford, A, Caterson, B & Hammond, CL 2013, Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis. PloS one, vol 8., pp. e75787
- Hayes, AJ, Mitchell, RE, Bashford, A, Reynolds, S, Caterson, B & Hammond, CL 2013, Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental dynamics : an official publication of the American Association of Anatomists.
- Huitema, L, Apschner, A, Logister, I, Spoorendonk, K, Bussmann, J, Hammond, CL & Schulte-Merker, S 2012, Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. Proceedings of the National Academy of Sciences of the United States of America, vol 109., pp. 21372-7
- Mitchell, RE, Huitema, l, Skinner, R, Brunt, LH, Severn, C, Schulte-Merker, S & Hammond, CL 2012, New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis & Cartilage, vol 21., pp. 269-78
- Hammond, CL & Moro, E 2012, Using transgenic reporters to visualize bone and cartilage signaling during development in vivo.. Frontiers in Endocrinology.
- Knopf., F, Hammond, C, Chekuru, A, Kurth, T, Hans, S, Weber, C, Mahatma, G, Fisher, S, Brand, M, Schulte-Merker, S & Weidinger, G 2011, Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell, vol 20., pp. 713 - 724
- Vanoevelen, J, Janssens, A, Huitema, L, Hammond, C, Metz, J, Flik, G, Voets, T & Schulte-merker, S 2011, Trpv5/6 is vital for epithelial calcium uptake and bone formation. The FASEB Journal, vol 25 (9)., pp. 3197 - 3207
- Hammond, C & schulte-merker, S 2009, Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling. Development, vol 136., pp. 3991 - 4000
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