Dr Kate Nobes

Research summary

We are investigating the cell and molecular mechanisms that underlie guided cell migrations during development and repair of the nervous system. A major focus of the lab is how extracellular guidance molecules regulate signalling pathways to direct cell movement via the Rho and Ras-related GTPases.

Eph receptor tyrosine kinases and their ligands, the ephrins, are surface-tethered proteins that direct cell migrations and movements in a wide range of processes in both developing and adult tissues. In the nervous system their functions include guiding migrations of neuronal growth cones and neural crest cells during vertebrate embryogenesis and the maintenance and modification ...

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Recent publications

• Kadir, S, Astin, JW, tahtamouni, L, Martin, P & Nobes, CD. ‘Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion’, Journal of Cell Science, 124, (pp. 2642-2653), 2011
• Wang, Y, Nakayama, M, Pitulescu, ME, Schmidt, TS, Bochenek, ML, Sakakibara, A, Adams, S, Davy, A, Deutsch, U, Luthi, U, Barberis, A, Benjamin, LE, Makinen, T, Nobes, CD & Adams, RH. ‘Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis’, Nature, 465 (7297), (pp. 483-489), 2010

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View complete publications list in the University of Bristol publications system