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Professor Sergey Kasparov

Professor Sergey Kasparov

Professor Sergey Kasparov
MD, PhD(Moscow)

Professor in Molecular Physiology

Area of research

Physiological Genomics of Central Cardio-Vascular Control

Office E9
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 2275

Summary

My primary interst is the interplay between the neurones and the most abundant glial population of the central nervous sytesm - the astrocytes. Together with my colleagues, AG Teschemacher (UOB) and AV Gourine (UCL) we are woriking to establish functional contribution of astrocytes to various functions within mammalian brainstem including regulation of the autonomic functions and respiration. We are also interested in the interplay between astrocytes and central noradrenergic neurones, which costitute one of the most powerful modulatory mechanisms of the brain. Indeed, central noradrenergic mechanisms are involved in regulation of vigilance, cognition, sleep, appetite, pain and a variety of other essential functions. Our main hypothesis is that central noradrenergic neurones intimately communicate with astrocytes and via this link affect brain function. We have also demonstrated that astrocytes located in the ventral medulla play an important role in the chemo-sentitivity of the brain, one of the most important central homeostatic mechanisms. Finally we are interested in the neuro-glia-vascular interface, which controls the flow of blood and chemicals in and out of the brain. One of the projects we are currently carrying out looks at the glial contribution ot fMRI, a powerful imaging technology commonly used these days to assess brain function. The other prominent theme is how changes in neuro-glia-vascular interface affect autonomic regulation and contribute to hypertension and other cardio-vascular disease via increases in sympathetic tone.

We actively use and develop optogenetics, viral gene transfer, confocal imaging, fluorescent genetically encoded indicators and other modern technologies. 

Activities / Findings

  • Central effects of angiotensin II
  • Central Angiotensin II & Arterial Pressure Control
  • Targeting of specific physiological phenotypes of NTS neurones
  • GABAergic transmission in NTS.

Teaching

Medicine year 1:

  • Cell and its organelles
  • Cell division and cells as components of tissue
  • Intercellular communication
  • Autonomic nervous system
  • Endocrine system
  • Homeostasis 

Medicine year 2 tutorials:

  • Respiration
  • Renal
  • GI tract
  • Neurophysiology

Science year 2:

  • Introduction to DNA 

Keywords

  • blood pressure
  • brainstem
  • angiotensin II
  • nitric oxide
  • viral transfection
  • imaging
  • GFP
  • baroreceptor
  • neurogenic
  • electrophysiology

Skills

  • Stroke
  • retinopathy
  • hypertension
  • kidney disease
  • mycardial infarction
  • atherosclerosis

Processes and functions

  • Blood pressure regulation
  • homeostasis
  • processing information in the brainstem
  • brainstem control mechanisms

Methodologies

  • Confocal microscopy
  • viral transvection
  • adenoviral
  • lentiviral
  • in vitro slices
  • imaging
  • fluorescence microscopy
  • electrophysiology

Links

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Professor Julian Paton - University of Bristol

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