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Professor Sergey Kasparov

Professor Sergey Kasparov

Professor Sergey Kasparov
M.D., Ph.D.(Moscow)

Professor in Molecular Physiology

Area of research

Physiological Genomics of Central Cardio-Vascular Control

Office E9
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 2275

Summary

My primary interst is the interplay between the neurones and the most abundant glial population of the central nervous sytesm - the astrocytes. Together with my colleagues, AG Teschemacher (UOB) and AV Gourine (UCL) we are woriking to establish functional contribution of astrocytes to various functions within mammalian brainstem including regulation of the autonomic functions and respiration. We are also interested in the interplay between astrocytes and central noradrenergic neurones, which costitute one of the most powerful modulatory mechanisms of the brain. Indeed, central noradrenergic mechanisms are involved in regulation of vigilance, cognition, sleep, appetite, pain and a variety of other essential functions. Our main hypothesis is that central noradrenergic neurones intimately communicate with astrocytes and via this link affect brain function. We have also demonstrated that astrocytes located in the ventral medulla play an important role in the chemo-sentitivity of the brain, one of the most important central homeostatic mechanisms. Recently with our colleagues we have shown that astrocytes in the respiratory and pre-sympathetic areas of the medulla critifcally influence the aerobic exercise capacity in rodents, further implicating astrocytes in control of cardio-respriatory circuits of the brain. We also have a strong interest to new drug targets found on astrocytes and have identified some receptors which mediate potent neuroprotection. Finally, we have projects on glioblastoma, trying to find novel mechanisms to control or treat this devastating tumor of the brain.

We actively use and develop optogenetics, viral gene transfer, confocal imaging, fluorescent genetically encoded indicators and other modern technologies. 

Activities / Findings

  • Central effects of angiotensin II
  • Central Angiotensin II & Arterial Pressure Control
  • Targeting of specific physiological phenotypes of NTS neurones
  • GABAergic transmission in NTS.

Teaching

Medicine year 1:

  • Cell and its organelles
  • Cell division and cells as components of tissue
  • Intercellular communication
  • Autonomic nervous system
  • Endocrine system
  • Homeostasis 

Medicine year 2 tutorials:

  • Respiration
  • Renal
  • GI tract
  • Neurophysiology

Science year 2:

  • Introduction to DNA 

Keywords

  • blood pressure
  • brainstem
  • angiotensin II
  • nitric oxide
  • viral transfection
  • imaging
  • GFP
  • baroreceptor
  • neurogenic
  • electrophysiology

Skills

  • Stroke
  • retinopathy
  • hypertension
  • kidney disease
  • mycardial infarction
  • atherosclerosis

Processes and functions

  • Blood pressure regulation
  • homeostasis
  • processing information in the brainstem
  • brainstem control mechanisms

Methodologies

  • Confocal microscopy
  • viral transvection
  • adenoviral
  • lentiviral
  • in vitro slices
  • imaging
  • fluorescence microscopy
  • electrophysiology

Links

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Professor Julian Paton - University of Bristol

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