Professor Sergey Kasparov

Research summary

We work closely with Professor Julian Paton to investigate the roles of angiotensin II, nitric oxide and the neurotransmitter GABA, in the central control mechanisms responsible for maintaining blood pressure at normal levels.

It is vital that blood pressure is tightly regulated in order to supply all major organs with blood. `Essential hypertension' describes the condition where blood pressure is higher than normal over a prolonged period of time. This can lead to atherosclerosis, retinopathy, kidney disease, myocardial infarction and stroke.

Angiotensin II is a peptide that acts on blood vessel walls to modify arterial pressure. Blocking its action brings ...

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Recent publications

• Waki, H, Hendy, EB, Hindmarch, CCT, Gouraud, S, Toward, M, Kasparov, S, Murphy, D & Paton, JFR 2013, ‘Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats’. Hypertension, vol 61., pp. 194-201
• Kasimov, V, Larina, O, Castaldo, C, Marina, N, Patrushev, M, Kasparov, S & Gourine, A 2013, ‘Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia’. J. Neurosci, vol 33., pp. 435-441

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View complete publications list in the University of Bristol publications system