Dr Stuart Mundell

Research summary

G protein-coupled receptors (GPCRs), one of the largest protein families in the human genome, are the most tractable set of therapeutic targets for novel drug design.  GPCRs are regulated in a dynamic and complex manner, and are not static entities inserted into the plasma membrane of cells. My research examines the regulatory mechanisms controlling GPCR traffic whilst assessing the impact of such mechanisms on signalling pathways that initiate important physiological responses. In order to examine these questions we use both biochemical and imaging techniques to study receptor movement and function.

Presently we are examining the regulation of P2Y1 and P2Y12 ...

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Recent publications

• Cunningham, MR, McIntosh, KA, Pediani, JD, Robben, J, Cooke, AE, Nilsson, M, Gould, GW, Mundell, S, Milligan, G & Plevin, R 2012, ‘Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)’. Journal of Biological Chemistry, vol 287., pp. 16656-69
• Ferreira, F, Foley, M, Cooke, A, Cunningham, M, Smith, G, Woolley, R, Henderson, G, Kelly, E, Mundell, S & Smythe, E 2012, ‘Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation’. Current biology : CB, vol 22., pp. 1361-70

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View complete publications list in the University of Bristol publications system