G protein-coupled receptors (GPCRs), one of the largest protein families in the human genome, are the most tractable set of therapeutic targets for novel drug design. GPCRs are regulated in a dynamic and complex manner, and are not static entities inserted into the plasma membrane of cells. My research examines the regulatory mechanisms controlling GPCR traffic whilst assessing the impact of such mechanisms on signalling pathways that initiate important physiological responses. In order to examine these questions we use both biochemical and imaging techniques to study receptor movement and function.
Presently we are examining the regulation of P2Y1 and P2Y12 ...
View complete publications list in the University of Bristol publications system
Edit this profile If you are Dr Stuart Mundell, you can edit this page. Login required.
All details on one page > for printing etc.