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Publication - Dr Duncan Casey

    Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature

    Citation

    Casey, D, Charalambous, K, Gee, A, Law, RV & Ces, O, 2014, ‘Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature’. Journal of the Royal Society Interface, vol 11.

    Abstract

    Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood-brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.

    Full details in the University publications repository