Human podocyte cell line

Originally developed by Prof Saleem and colleagues at the University of Bristol, the colloquially named ‘Saleemocyte’ is known and used world-wide. It is a unique and representative tool for the study of human glomerular disease in-vitro.

The conditionally immortalised podocyte cell line allows an in-vitro process of maturation analogous to the development and maturation of podocytes in-vivo. The result is a homogenous, stable cell source that shows expression of key antigenic markers of differentiated in vivo podocytes. These include the novel podocyte proteins nephrin, podocin, CD2AP and synapodin.

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