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Publication - Dr Gemma Lasseter

    PRImary care Streptococcal Management (PRISM) study

    in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study

    Citation

    Little, P, Hobbs, FR, Moore, M, Mant, D, Williamson, I, McNulty, C, Lasseter, G, Cheng, ME, Leydon, G, McDermott, L, Turner, D, Pinedo-Villanueva, R, Raftery, J, Glasziou, P & Mullee, M, 2014, ‘PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study’. Health Technology Assessment, vol 18., pp. 1-102

    Abstract

    Antibiotics are still prescribed to most patients attending primary care with acute sore throat, despite evidence that there is modest benefit overall from antibiotics. Targeting antibiotics using either clinical scoring methods or rapid antigen detection tests (RADTs) could help. However, there is debate about which groups of streptococci are important (particularly Lancefield groups C and G), and uncertainty about the variables that most clearly predict the presence of streptococci.

    Full details in the University publications repository