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Professor George Davey Smith
Professor George Davey Smith
Professor of Clinical Epidemiology
MA(Oxon), MD,BChir(Cantab), MSc(Lond)
George Davey Smith is a clinical epidemiologist whose research has pioneered (1) understanding of the causes and alleviation of health inequalities; (2) lifecourse epidemiology (3) systematic reviewing of evidence of effectiveness of health care and health policy interventions (4) population health contributions of the new genetics. He has published over 700 peer-reviewed journal articles, 15 books/edited collections and numerous editorials, commentaries and reviews. Major contributions include: a) the demonstration of the influence of childhood socio-economic deprivation on cause-specific morbidity and mortality patterns in adult life; b) methodological developments in meta-analysis (One paper has over 3000 citations to date); c) elucidation of factors underlying socio-economic differences in morbidity and mortality in the UK, US, Norway and India d) the development and application of Mendelian randomisation approaches, interrogating the causal role of behavioural factors (such as alcohol consumption) and intermediate phenotypes (such as fibrinogen and C-reactive protein) on different health outcomes. He is an ISI highly cited scholar (h index greater than 90 – this needs to be calculated manually as citations are under various guises, Smith GD, Davey Smith G, Davey SG, amongst others) and Foreign Associate of the Institute of Medicine. He is co-editor of the International Journal of Epidemiology (during his tenure the impact factor has increased from less than 2 to over 5), has sat on the MRC Public Health and Health Services Research and the MRC Physiological Medicine and Infection Boards and the MRC Military Health Research Advisory Group. He has established or has been central to the running of a large number of epidemiological cohort studies involving detailed clinical and biomarker assessments. He is currently Scientific Director of the Avon Longitudinal Study of Parents and Children; during his tenure considerable funds have been secured for ongoing follow-up and the resource has become widely utilised by the scientific community. He is also awarded Directorship of the MRC Centre for Causal Analyses in Translational Epidemiology in 2007 and is Director of the Wellcome Trust 4 year PhD programme in Lifecourse and Genetic Epidemiology at the Department of Social Medicine, University of Bristol.
- Kemp, J, Medina-Gomez, C, Estrada, K, St. Pourcain, B, Heppe, D, Warrington, N, Oei, L, Ring, S, Cruithof, C, Timpson, NJ, Wolber, L, Reppe, S, Gautvik, KM, Grundberg, E, GE, B, Eerden, BVd, Peppel, JVd, Hibbs, M, Ackert-Bicknell, C, Choi, K, Koller, D, Econs, M, Williams, F, Foroud, T, Zillikens, M, Ohlsson, C, Hofman, A, Uitterlinden, A, Smith, GD, Jaddoe, V, Tobias, JH, Rivadeneira, F & Evans, D 2014, Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet, vol 10.
- Ware, JJ, Timpson, NJ, Smith, GD & Munafò, MR 2014, A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. BMC Medical Genetics, vol 15., pp. 13
- Taylor, AE, Fluharty, ME, Bjørngaard, JH, Gabrielsen, ME, Skorpen, F, Marioni, RE, Campbell, A, Engmann, J, Mirza, SS, Loukola, A, Laatikainen, T, Partonen, T, Kaakinen, M, Ducci, F, Cavadino, A, Husemoen, LLN, Ahluwalia, TS, Jacobsen, RK, Skaaby, T, Ebstrup, JF, Mortensen, EL, Minica, CC, Vink, JM, Willemsen, G, Marques-Vidal, P, Dale, CE, Amuzu, A, Lennon, LT, Lahti, J, Palotie, A, Räikkönen, K, Wong, A, Paternoster, L, Wong, AP, Horwood, LJ, Murphy, M, Johnstone, EC, Kennedy, MA, Pausova, Z, Paus, T, Ben-Shlomo, Y, Nohr, EA, Kuh, D, Kivimaki, M, Eriksson, JG, Morris, RW, Casas, JP, Preisig, M, Boomsma, DI, Linneberg, A, Power, C, Hyppönen, E, Veijola, J, Jarvelin, M-R, Korhonen, T, Tiemeier, H, Kumari, M, Porteous, DJ, Hayward, C, Romundstad, PR, Smith, GD & Munafò, MR 2014, Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open, vol 4., pp. e006141
- Davies, NM, Scholder, SVHK, Farbmacher, H, Burgess, S, Windmeijer, F & Smith, GD 2014, The Many Weak Instruments Problem and Mendelian Randomization. Statistics in Medicine.
- Martin, RM, Patel, R, Kramer, MS, Vilchuck, K, Bogdanovich, N, Sergeichick, N, Gusina, N, Foo, Y, Palmer, T, Thompson, J, Gillman, MW, Smith, GD & Oken, E 2014, Effects of Promoting Longer-Term and Exclusive Breastfeeding on Cardiometabolic Risk Factors at Age 11.5 Years A Cluster-Randomized, Controlled Trial. Circulation, vol 129., pp. 321-329
- Nudel, R, Simpson, NH, Baird, G, O'Hare, A, Conti-Ramsden, G, Bolton, PF, Hennessy, ER, Ring, SM, Smith, GD, Francks, C, Paracchini, S, Monaco, AP, Fisher, SE, Newbury, DF & 2014, Genome- wide association analyses of child genotype effects and parent- of- origin effects in specific language impairment. Genes, Brain and Behavior, vol 13., pp. 418-429
- Benyamin, B, St Pourcain, B, Davis, O, Davies, G, Hansell, N, Brion, M-J, Kirkpatrick, R, Cents, R, Franic, S, Miller, M, Haworth, C, Meaburn, E, Price, T, Evans, D, Timpson, N, Kemp, J, Ring, S, McArdle, W, Medland, S, WTCCC2, +WTCCC, authors, +, Smith, GD, Deary, I, Plomin, R & Visscher, P 2014, Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Molecular Psychiatry, vol 19., pp. 253-258
- Taylor, AE, Morris, RW, Fluharty, ME, Paternoster, L, Ben-Shlomo, Y, Smith, GD, Lawlor, DA & Munafo, MR 2014, Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics.
- St Pourcain, B, Skuse, DH, Mandy, WP, Wang, K, Hakonarson, H, Timpson, NJ, Evans, DM, Kemp, JP, Ring, SM, McArdle, WL, Golding, J & Smith, GD 2014, Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. Molecular autism, vol 5., pp. 18
- Matsuzaki, M, Kuper, H, Kulkarni, B, Radhakrishna, K, Viljakainen, H, Taylor, A, Sullivan, R, Bowen, L, Tobias, JH, Ploubidis, G, Wells, J, Prabhakaran, D, Smith, GD, Ebrahim, SBJ, Ben-Shlomo, Y & Kinra, S 2014, life course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (ACAPS). Am J Clin Nutr, vol 99., pp. 1450-9
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