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Professor George Davey Smith

Professor George Davey Smith

Professor George Davey Smith
MA(Oxon), MD,BChir(Cantab), MSc(Lond)

Professor of Clinical Epidemiology

Office OS10. Email Julia.Mackay@bristol.ac.uk
Oakfield House,
Oakfield Grove, Clifton BS8 2BN
(See a map)

+44 (0) 117 3310095

Summary

Biography

George Davey Smith is a clinical epidemiologist whose research has pioneered (1) understanding of the causes and alleviation of health inequalities; (2) lifecourse epidemiology (3) systematic reviewing of evidence of effectiveness of health care and health policy interventions (4) population health contributions of the new genetics. He has published over 1000 peer-reviewed journal articles, 15 books/edited collections and numerous editorials, commentaries and reviews. Major contributions include: a) the demonstration of the influence of childhood socio-economic deprivation on cause-specific morbidity and mortality patterns in adult life; b) methodological developments in meta-analysis; c) elucidation of factors underlying socio-economic differences in morbidity and mortality in the UK, US, Norway and India d) the development and application of Mendelian randomisation approaches, interrogating the causal role of behavioural factors (such as alcohol consumption) and intermediate phenotypes (such as fibrinogen and C-reactive protein) on different health outcomes; e) application of causal analysis approaches to epigenetic data.  He is an ISI highly cited scholar and Foreign Associate of the National Academy of Medicine Fellow of the Royal Society of Edinburgh. He is co-editor of the International Journal of Epidemiology (during his tenure the impact factor has increased from less than 2 to over 9), has sat on the MRC Public Health and Health Services Research, Physiological Medicine and Infection Boards and the MRC Military Health Research Advisory Group and Global Health Group. He is on the Wellcome Trust Science Funding Interview Panel. He has established or has been central to the running of a large number of epidemiological cohort studies involving detailed clinical and biomarker assessments. He is currently Scientific Director of the Avon Longitudinal Study of Parents and Children; and became Director of the MRC Centre for Causal Analyses in Translational Epidemiology in 2007 and of the MRC Integrative Epidemiology Unit in 2013.  He is Director of the Wellcome Trust 4 year PhD programme in Lifecourse and Genetic Epidemiology at the School of Social and Community Medicine, University of Bristol.

Activities / Findings

George Davey Smith is a clinical epidemiologist whose research has pioneered (1) understanding of the causes and alleviation of health inequalities; (2) lifecourse epidemiology (3) systematic reviewing of evidence of effectiveness of health care and health policy interventions (4) population health contributions of the new genetics. He has published over 1000 peer-reviewed journal articles, 15 books/edited collections and numerous editorials, commentaries and reviews. Major contributions include: a) the demonstration of the influence of childhood socio-economic deprivation on cause-specific morbidity and mortality patterns in adult life; b) methodological developments in meta-analysis; c) elucidation of factors underlying socio-economic differences in morbidity and mortality in the UK, US, Norway and India d) the development and application of Mendelian randomisation approaches, interrogating the causal role of behavioural factors (such as alcohol consumption) and intermediate phenotypes (such as fibrinogen and C-reactive protein) on different health outcomes; e) application of causal analysis approaches to epigenetic data.  He is an ISI highly cited scholar and Foreign Associate of the National Academy of Medicine Fellow of the Royal Society of Edinburgh. He is co-editor of the International Journal of Epidemiology (during his tenure the impact factor has increased from less than 2 to over 9), has sat on the MRC Public Health and Health Services Research, Physiological Medicine and Infection Boards and the MRC Military Health Research Advisory Group and Global Health Group. He is on the Wellcome Trust Science Funding Interview Panel. He has established or has been central to the running of a large number of epidemiological cohort studies involving detailed clinical and biomarker assessments. He is currently Scientific Director of the Avon Longitudinal Study of Parents and Children; and became Director of the MRC Centre for Causal Analyses in Translational Epidemiology in 2007 and of the MRC Integrative Epidemiology Unit in 2013.  He is Director of the Wellcome Trust 4 year PhD programme in Lifecourse and Genetic Epidemiology at the School of Social and Community Medicine, University of Bristol.

Recent publications

  • Swerdlow, DI, Preiss, D, Kuchenbaecker, KB, Holmes, MV, Engmann, JEL, Shah, T, Sofat, R, Stender, S, Johnson, PCD, Scott, RA, Leusink, M, Verweij, N, Sharp, SJ, Guo, Y, Giambartolomei, C, Chung, C, Peasey, A, Amuzu, A, Li, K, Palmen, J, Howard, P, Cooper, JA, Drenos, F, Li, YR, Lowe, G, Gallacher, J, Stewart, MCW, Tzoulaki, I, Buxbaum, SG, Der A, DLV, Forouhi, NG, Onland-Moret, NC, Der Schouw, YTV, Schnabel, RB, Hubacek, JA, Kubinova, R, Baceviciene, M, Tamosiunas, A, Pajak, A, Topor-Madry, R, Stepaniak, U, Malyutina, S, Baldassarre, D, Sennblad, B, Tremoli, E, De Faire, U, Veglia, F, Ford, I, Jukema, JW, Westendorp, RGJ, De Borst, GJ, De Jong, PA, Algra, A, Spiering, W, Der Zee, AHMV, Klungel, OH, De Boer, A, Doevendans, PA, Eaton, CB, Robinson, JG, Duggan, D, Kjekshus, J, Downs, JR, Gotto, AM, Keech, AC, Marchioli, R, Tognoni, G, Sever, PS, Poulter, NR, Waters, DD, Pedersen, TR, Amarenco, P, Nakamura, H, McMurray, JJV, Lewsey, JD, Chasman, DI, Ridker, PM, Maggioni, AP, Tavazzi, L, Ray, KK, Seshasai, SRK, Manson, JE, Price, JF, Whincup, PH, Morris, RW, Lawlor, DA, Smith, GD, Ben-Shlomo, Y, Schreiner, PJ, Fornage, M, Siscovick, DS, Cushman, M, Kumari, M, Wareham, NJ, Verschuren, WMM, Redline, S, Patel, SR, Whittaker, JC, Hamsten, A, Delaney, JA, Dale, C, Gaunt, TR, Wong, A, Kuh, D, Hardy, R, Kathiresan, S, Castillo, BA, Der Harst, PV, Brunner, EJ, Tybjaerg-Hansen, A, Marmot, MG, Krauss, RM, Tsai, M, Coresh, J, Hoogeveen, RC, Psaty, BM, Lange, LA, Hakonarson, H, Dudbridge, F, Humphries, SE, Talmud, PJ, Kivimäki, M, Timpson, NJ, Langenberg, C, Asselbergs, FW, Voevoda, M, Bobak, M, Pikhart, H, Wilson, JG, Reiner, AP, Keating, BJ, Hingorani, AD & Sattar, N 2015, ‘HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials’. J Psychopharmacol, vol 385., pp. 351-361
  • Gaunt, TR & Smith, GD 2015, ‘ENOS and coronary artery disease: Publication bias and the eclipse of hypothesis-driven meta-analysis in genetic association studies’. Gene, vol 556., pp. 257-258
  • Lee, KWK, Richmond, R, Hu, P, French, L, Shin, J, Bourdon, C, Reischl, E, Waldenberger, M, Zeilinger, S, Gaunt, T, McArdle, W, Ring, S, Woodward, G, Bouchard, L, Gaudet, D, Smith, GD, Relton, C, Paus, T & Pausova, Z 2015, ‘Prenatal exposure to maternal cigarette smoking and DNA methylation: Epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age’. Environmental Health Perspectives, vol 123., pp. 193-199
  • Relton, CL, Gaunt, T, McArdle, W, Ho, K, Duggirala, A, Shihab, H, Woodward, G, Lyttleton, O, Evans, DM, Reik, W, Paul, Y-L, Ficz, G, Ozanne, SE, Wipat, A, Flanagan, K, Lister, A, Heijmans, BT, Ring, SM & Smith, GD 2015, ‘Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)’. International journal of epidemiology.
  • Wade, KH, Forouhi, NG, Cook, DG, Johnson, P, McConnachie, A, Morris, RW, Rodriguez, S, Ye, Z, Ebrahim, S, Padmanabhan, S, Watt, G, Bruckdorfer, KR, Wareham, NJ, Whincup, PH, Chanock, S, Sattar, N, Lawlor, DA, Smith, GD & Timpson, NJ 2015, ‘Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid’. The American Journal of Clinical Nutrition, vol 101., pp. 202-9
  • Timpson, NJ, Walter, K, Min, JL, Tachmazidou, I, Malerba, G, Shin, S-Y, Chen, L, Futema, M, Southam, L, Iotchkova, V, Cocca, M, Huang, J, Memari, Y, McCarthy, S, Danecek, P, Muddyman, D, Mangino, M, Menni, C, Perry, JRB, Ring, SM, Gaye, A, Dedoussis, G, Farmaki, A-E, Burton, P, Talmud, PJ, Gambaro, G, Spector, TD, Smith, GD, Durbin, R, Richards, JB, Humphries, SE, Zeggini, E, Soranzo, N & 2015, ‘Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans’. Nature Communications, vol 6., pp. 7171
  • Warrington, NM, Howe, LD, Paternoster, L, Kaakinen, M, Herrala, S, Huikari, V, Wu, YY, Kemp, JP, Timpson, NJ, St Pourcain, B, Smith, GD, Tilling, K, Jarvelin, M-R, Pennell, CE, Evans, DM, Lawlor, DA, Briollais, L & Palmer, LJ 2015, ‘A genome-wide association study of body mass index across early life and childhood’. International journal of epidemiology.
  • Yaghootkar, H, Stancáková, A, Freathy, RM, Vangipurapu, J, Weedon, MN, Xie, W, Wood, AR, Ferrannini, E, Mari, A, Ring, SM, Lawlor, DA, Smith, GD, Jørgensen, T, Hansen, T, Pedersen, O, Steinthorsdottir, V, Guðbjartsson, DF, Thorleifsson, G, Thorsteinsdottir, U, Stefansson, K, Hattersley, AT, Walker, M, Morris, AD, McCarthy, MI, Palmer, C, Laakso, M & Frayling, TM 2015, ‘Association analysis of 29,956 individuals confirms that a low frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion’. Diabetes.
  • Valk, RJPvd, Kreiner-Møller, E, Kooijman, MN, Guxens, M, Stergiakouli, E, Sääf, A, Bradfield, JP, Geller, F, Hayes, MG, Cousminer, DL, Körner, A, Thiering, E, Curtin, JA, Myhre, R, Huikari, V, Joro, R, Kerkhof, M, Warrington, NM, Pitkänen, N, Ntalla, I, Horikoshi, M, Veijola, R, Freathy, RM, Teo, Y-Y, Barton, SJ, Evans, DM, Kemp, JP, St Pourcain, B, Ring, SM, Smith, GD, Bergström, A, Kull, I, Hakonarson, H, Mentch, FD, Bisgaard, H, Chawes, B, Stokholm, J, Waage, J, Eriksen, P, Sevelsted, A, Melbye, M, Duijn, CMv, Medina-Gomez, C, Hofman, A, Jongste, JCd, Taal, HR, Uitterlinden, AG, Armstrong, LL, Eriksson, J, Palotie, A, Bustamante, M, Estivill, X, Gonzalez, JR, Llop, S, Kiess, W, Mahajan, A, Flexeder, C, Tiesler, CMT, Murray, CS, Simpson, A, Magnus, P, Sengpiel, V, Hartikainen, A-L, Keinanen-Kiukaanniemi, S, Lewin, A, Alves, ADSC, Blakemore, AI, Buxton, JL, Kaakinen, M, Rodriguez, A, Sebert, S, Vaarasmaki, M, Lakka, T, Lindi, V, Gehring, U, Postma, DS, Ang, W, Newnham, JP, Lyytikäinen, L-P, Pahkala, K, Raitakari, OT, Panoutsopoulou, K, Zeggini, E, Boomsma, DI, Groen-Blokhuis, M, Ilonen, J, Franke, L, Hirschhorn, JN, Pers, TH, Liang, L, Huang, J, Hocher, B, Knip, M, Saw, S-M, Holloway, JW, Melén, E, Grant, SFA, Feenstra, B, Lowe, WL, Widén, E, Sergeyev, E, Grallert, H, Custovic, A, Jacobsson, B, Jarvelin, M-R, Atalay, M, Koppelman, GH, Pennell, CE, Niinikoski, H, Dedoussis, GV, Mccarthy, MI, Frayling, TM, Sunyer, J, Timpson, NJ, Rivadeneira, F, Bønnelykke, K, Jaddoe, VWV & 2015, ‘A novel common variant in DCST2 is associated with length in early life and height in adulthood’. Human Molecular Genetics, vol 24., pp. 1155-68
  • Simpkin, AJ, Suderman, M, Gaunt, TR, Lyttleton, O, McArdle, WL, Ring, SM, Tilling, K, Smith, GD & Relton, CL 2015, ‘Longitudinal analysis of DNA methylation associated with birth weight and gestational age’. Human Molecular Genetics.

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