Dr Luisa Zuccolo

Summary

Expertise

My main interest is in preventable determinants that impact on health and disease. In particular, I completed a research project on alcohol and prostate cancer, and used new techniques that borrow from genetics to see whether alcohol causes an increase in the risk of this cancer or an increase in the risk of being diagnosed (but not of cancer progression). Working on this has given me the opportunity to research common genetic variation predisposing to higher alcohol consumption in the population. I am currently involved in new projects to explore how problem drinking can be transmitted across generations, and what consequences the parents? drinking behaviour has on the offspring?s cognition and behaviour. This work is based on the 'Children of the 90's' study.

Memberships

Organisations

Bristol Medical School (PHS)

Other sites

• Cancer
• Populationhealth

Centres, collaborations and units

• Centre for Academic Mental Health

Recent publications

• , Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, DM, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Choquet, H, Docherty, AR, Faul, JD, Foerster, JR, Fritsche, LG, Gabrielsen, ME, Gordon, SD, Haessler, J, Hottenga, J-J, Huang, H, Jang, S-K, Jansen, PR, Ling, Y, Mägi, R, Matoba, N, McMahon, G, Mulas, A, Orrù, V, Palviainen, T, Pandit, A, Reginsson, GW, Skogholt, AH, Smith, JA, Taylor, AE, Turman, C, Willemsen, G, Young, H, Young, KA & others 2019, ‘Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use’. Nature Genetics.
• Sharp, G, Arathimos, R, Reese, S, Page, C, Felix, JF, Kupers, L, Rifas-Shiman, SL, Liu, C, Burrows, K, Zhao, S, Magnus, M, Duijts, L, Corpeleijn, E, DeMeo, D, Litonjua, A, Baccarelli, A, Hivert, M-F, Oken, E, Snieder, H, Jaddoe, VWV, Nystad, W, London, S, Relton, C & Zuccolo, L, 2018, ‘Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts’. Epigenomics.
• Brunner, C, Davies, NM, Martin, R, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Wiklund, F, Grönberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Neal, DE, Donovan, J, Pashayan, N, Khaw, K-T, Stanford, JL, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, MR, Pandha, H, & Zuccolo, L, 2017, ‘Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study’. International Journal of Cancer, vol 140., pp. 75-85
• Mamluk, L, Edwards, H, Savović, J, Leach, V, Jones, T, Moore, T, Ijaz, S, Lewis, S, Donovan, J, Lawlor, D, Smith, GD, Fraser, A & Zuccolo, L, 2017, ‘Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses’. BMJ Open, vol 7.
• Gregson, CL & Zuccolo, L, 2017, ‘Letter regarding 'Does a bit of alcohol turn off inflammation and improve health?'’. Age and Ageing, vol 46., pp. 158-159
• Zuccolo, L & Holmes, MV, 2017, ‘Commentary: Mendelian randomization-inspired causal inference in the absence of genetic data’. International Journal of Epidemiology, vol 46., pp. 962-965
• Zuccolo, L, DeRoo, L, Wills, A, Smith, GD, Surén, P, Roth, C, Stoltenberg, C & Magnus, P, 2016, ‘Pre-conception and prenatal alcohol exposure from mothers and fathers drinking and head circumference: results from the Norwegian Mother-Child Study (MoBa)’. Scientific Reports, vol 7.
• Taylor, M, Simpkin, A, Haycock, P, Dudbridge, F & Zuccolo, L, 2016, ‘Exploration of a polygenic risk score for alcohol consumption: A longitudinal analysis from the ALSPAC cohort’. PLoS ONE, vol 11.
• Murray, J, Burgess, S, Zuccolo, L, Hickman, M, Gray, R & Lewis, SJ, 2015, ‘Moderate alcohol drinking in pregnancy increases risk for children's persistent conduct problems: causal effects in a Mendelian randomisation study’. Journal of Child Psychology and Psychiatry.
• O'Keeffe, LM, Kearney, PM, Greene, RA, Zuccolo, L, Tilling, K, Lawlor, DA & Howe, LD, 2015, ‘Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study’. Drug and Alcohol Dependence, vol 153., pp. 323-329

View complete publications list in the University of Bristol publications system