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Dr Matthew Suderman


In 2005 I received a PhD in Computer Science at McGill University.  My thesis investigated methods for automatically drawing networks on 2-dimensional surfaces. Hoping to apply these methods to biological data, I signed up for postdoctoral research in bioinformatics under the supervision of Michael Hallett (bioinformatics) and later Moshe Szyf (epigenetics). There my focus turned from networks to epigenetics. For the next several years I analyzed  genome-wide DNA methylation and transcriptional profiles from a variety of tissues and organisms for associations with various exposures and disease states. These analyses suggested that blood DNA methylation profiles may be used to piece together accurate exposure histories to better predict later health outcomes, but that further progress would require analysis of methylation profiles from large, well-characterized human cohorts. This led to my appointment in 2013 as a researcher at the University Bristol to analyze methylation profiles from members of ALSPAC under the supervision of Caroline Relton and George Davey Smith.