Following undergraduate studies in Oxford, I started research for a PhD at the Department of Social Medicine, University of Bristol, in 2003. Here I was part of the development of Mendelian randomisation, using genetic variants as instrumental variables to investigate the causal role of C-reactive protein in cardiometabolic risk.
In December 2006 I was seconded to The Wellcome Trust Centre for Human Genetics, Oxford, where I worked with teams led by Profs Cardon and McCarthy. I worked as part of the Wellcome Trust Case Control Consortium’s type 2 team and on the first confirmed common gene variant associated with adiposity.
In 2007/8 I began a Lectureship in genetic epidemiology at the MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol. This has matured into a full university supported Readership awarded in the summer of 2013.
My current research concerns the contribution of genetic factors to common, complex traits including the development and use of novel analytical approaches for assessing causality. I lead a programme of research for the undertaking of genotype based recall experiments within the MRC Integrated Epidemiology Unit and am co-chair of the cohorts group of the UK10K population based whole genome sequencing initiative.
I'm currently responsible for the Population Health Research Theme.
I teach a broad range of topics related to population health and genetics to both undergraduate and postgraduate students and use a variety of teaching methods for delivery and assessment. I have teach clinical epidemiology to first year medical undergraduates and unit lead for Community Orientated Medical Practice (COMP1 - with a focus on evidence based medicine and public health) for fourth year medical undergraduates.
View complete publications list in the University of Bristol publications system
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