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Dr Oliver Davis
Dr Oliver Davis
BA(Cantab.), MSc(Nott.), MSc(Kings College London), PhD(Kings College London), PGCert(Kings College London)
Reader in Statistical Genetics
Area of research
Genetic and environmental data science
Research summary
Genetic variation affects all complex human traits and disorders. However, which DNA variants affect us and how they have their effect depends on the environmental and developmental context. For example, some genetic influences may be apparent only in childhood, or only in the centre of large cities. Our lab uses emerging technologies to collect, analyse and visualize data from large population samples around the world, exploring the dynamic relationship between genotype and phenotype in humans.
We use techniques such as twin model-fitting and genome-wide analysis of ‘omics data, as well as developing our own new statistical and visual analysis approaches ...
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Biography
Oliver read Natural Sciences at the University of Cambridge before studying for an MSc and PhD in statistical behavioural genetics at the MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London. After his PhD, he was awarded a Sir Henry Wellcome Fellowship by the Wellcome Trust, spending time at the Wellcome Trust Centre for Human Genetics at the University of Oxford and the European Bioinformatics Unit near Cambridge. Towards the end of his fellowship he established a new lab at UCL Genetics Institute in London, before moving to Bristol in 2015.
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Selected publications
- Haworth, CMA & Davis, OSP, 2014, ‘From observational to dynamic genetics’. Frontiers in Genetics, vol 5.
- Davis, OSP, Band, G, Pirinen, M, Haworth, CMA, Meaburn, EL, Kovas, Y, Harlaar, N, Docherty, SJ, Hanscombe, KB, Trzaskowski, M, Curtis, CJC, Strange, A, Freeman, C, Bellenguez, C, Su, Z, Pearson, R, Vukcevic, D, Langford, C, Deloukas, P, Hunt, S, Gray, E, Dronov, S, Potter, SC, Tashakkori-Ghanbaria, A, Edkins, S, Bumpstead, SJ, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Jankowski, JAZ, Markus, HS, Mathew, CG, Palmer, CNA, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC & others 2014, ‘The correlation between reading and mathematics ability at age twelve has a substantial genetic component’. Nature Communications, vol 5.
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Recent publications
- Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Thornton, L, Hinney, A, Daly, M, Sullivan, PF, Zeggini, E, Breen, G, Bulik, CM, Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, Bulik-Sullivan, B, Ripke, S, Adan, R, Alfredsson, L, Ando, T, Andreassen, O, Aschauer, H, Baker, J, Barrett, J, Bencko, V, Bergen, A, Berrettini, W, Birgegård, A, Boni, C, Perica, VB, Brandt, H, Burghardt, R, Carlberg, L, Cassina, M & others 2017, ‘Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa’. American Journal of Psychiatry, vol 174., pp. 850-858
- Li, D, Chang, X, Connolly, JJ, Tian, L, Liu, Y, Bhoj, EJ, Robinson, N, Abrams, D, Li, YR, Bradfield, JP, Kim, CE, Li, J, Wang, F, Snyder, J, Lemma, M, Hou, C, Wei, Z, Guo, Y, Qiu, H, Mentch, FD, Thomas, KA, Chiavacci, RM, Cone, R, Li, B, Sleiman, PA, Hakonarson, H, Perica, VB, Franklin, CS, Floyd, JA, Thornton, LM, Huckins, LM, Southam, L, Rayner, NW, Tachmazidou, I, Schmidt, U, Tozzi, F, Kiezebrink, K, Hebebrand, J, Gorwood, P, Adan, RA & others 2017, ‘A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling’. Scientific Reports, vol 7.
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