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Professor Richard Martin
Professor Richard Martin
Professor of Clinical Epidemiology
BMedSci, BM,BS(Nott), MSc(Lond), MRCGP, PhD
My current principal areas of research are: i) prostate cancer aetiology (with a focus on metabolic factors such as the IGF system), predicting its progression and secondary and tertiary prevention of the disease via population-based screening and low-toxicity nutritional and lifestyle interventions; ii) the short- and long-term child and adult health effects of breastfeeding and early growth; and iii) uncovering unexpected beneficial and adverse effects of commonly prescribed drugs through pharmaco-epidemiological studies based on automated clinical databases such as the UK GPRD. I am lead principal investigator (with Jenny Donovan, Freddie Hamdy and David Neal) on a population-based cluster randomised controlled trial of PSA testing for prostate cancer (the CAP trial) that involves over 430,000 UK men and co-principal investigator (with Mike Kramer and Emily Oken) on the long-term follow-up of a cluster randomised controlled trial of a breastfeeding promotion intervention that involves over 17,000 children in the Republic of Belarus (the PROBIT trial). I am interested in robustly assessing the causality of observational associations using instrumental variables analysis, working in collaboration with Frank Windmeijer, George Davey Smith, Tom Palmer and Neil Davies. With Andy Ness (Director), Julian Hamilton-Shield and Ashley Cooper, I am on the executive committee of the Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle including Obesity (awarded to the University of Bristol and University Hospitals Bristol NHS Foundation Trust) and lead the prostate cancer theme within this unit. With Willie Hamilton, Mike Stevens, Rachel Dommet and Theresa Redaniel, I have a developing interest in the presentation and diagnosis of childhood, teenage and young adult cancers in primary care. I work closely with Jeff Holly on the role of the circulating IGF system in disease aetiology and progression.
I am currently Professor of Clinical Epidemiology in the School of Social and Community Medicine, University of Bristol. I qualified in Medicine from the University of Nottingham, trained and worked as a GP, and then built on an interest in epidemiology (that was first sparked during my intercalated BMedSci at Nottingham) by doing the MSc in Epidemiology at the London School of Hygiene and Tropical Medicine. I subsequently moved to Bristol to take up a Lecturer post and then a Wellcome Trust Research Training Fellowship in Clinical Epidemiology, and have worked at the School of Social and Community Medicine ever since.
I am Co-Director of Graduate Studies in the School of Social and Community Medicine (with Alan Montgomery). With George Davey Smith and Ian day, I run a Wellcome Trust 4-year PhD programme in Molecular, Genetic and Lifecourse epidemiology. I teach clinical epidemiology to first and fourth year medical students and am currently supervising 4 PhD students. I am tutor to 5 first and second year medical students. I am past examiner for the Faculty of Public Health Part A exam.
- Carreras-Torres, R, Johansson, M, Gaborieau, V, Haycock, P, Wade, K, Relton, C, Martin, R, Smith, GD & Brennan, P, 2017, The role of obesity, type 2 diabetes and metabolic factors in pancreatic cancer: A Mendelian randomization study. Journal of the National Cancer Institute.
- Mars, B, Heron, J, Gunnell, D, Martin, R, Thomas, K & Kessler, D, 2017, Prevalence and patterns of antidepressant switching amongst Primary Care patients in the UK. Journal of Psychopharmacology.
- Hamdy, FC, Donovan, J, Lane, A, Mason, M, Metcalfe, C, Davis, M, Peters, T, Turner, E, Martin, R & Walsh, E, 2016, Mortality and Clinical Outcomes at 10 years’ Follow-up in the ProtecT Trial. The New England Journal of Medicine, vol 375., pp. 1415-1424
- Taylor, A, Martin, R, Geybels, M, Stanford, JL, Shui, I, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Wiklund, F, Grönberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Neal, DE, Pashayan, N, Khaw, KT, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, MR, Pandha, H, PRACTICAL, CT, Donovan, J & Munafo, M, 2016, Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis. International Journal of Cancer.
- Carreras-Torres, R, Haycock, PC, Relton, CL, Martin, RM, Smith, GD, Kraft, P, Gao, C, Tworoger, S, Le Marchand, L, Wilkens, LR, Park, SL, Haiman, C, Field, JK, Davies, M, Marcus, M, Liu, G, Caporaso, NE, Christiani, DC, Wei, Y, Chen, C, Doherty, JA, Severi, G, Goodman, GE, Hung, RJ, Amos, CI, McKay, J, Johansson, M & Brennan, P, 2016, The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study. Scientific Reports, vol 6.
- Donovan, J, Hamdy, FC, Lane, A, Mason, M, Metcalfe, C, Walsh, E, Blazeby, J, Peters, T, Davis, M, Turner, E & Martin, R, 2016, Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. New England Journal of Medicine, vol 375., pp. 1425-1437
- Brunner, C, Davies, NM, Martin, R, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Wiklund, F, Grönberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Neal, DE, Donovan, J, Pashayan, N, Khaw, K-T, Stanford, JL, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, MR, Pandha, H, & Zuccolo, L, 2016, Alcohol Consumption and Prostate Cancer Incidence and Progression: a Mendelian Randomization Study. International Journal of Cancer.
- Bonilla, C, Lewis, S, Rowlands, M-A, Gaunt, T, Smith, GD, Gunnell, D, Palmer, T, Donovan, J, Hamdy, FC, Neal, DE, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Wiklund, F, Gronberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Pashayan, N, Khaw, K-T, Stanford, JL, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, MR, Pandha, H, PRACTICAL, CT, Lathrop, M & others 2016, Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels.. International Journal of Cancer, vol 139., pp. 1520-1533
- Greenwood, C, Clement, J, Dicken, A, Evans, J, Lyburn, I, Martin, R, Rogers, K, Stone, N & Zioupos, P, 2016, Towards new material biomarkers for fracture risk. Bone, vol 93., pp. 55-63
- Walker, V, Davies, N, Jones, T, Kehoe, P & Martin, R, 2016, Can commonly prescribed drugs be repurposed for the prevention or treatment of Alzheimer’s and other neurodegenerative diseases? Protocol for an observational cohort study in the UK Clinical Practice Research Datalink. BMJ Open, vol 6.
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