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Publication - Professor Stan Zammit

    Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences

    evidence from the Avon Longitudinal Study of Parents and Children

    Citation

    Madrid-Gambin, F, Föcking, M, Sabherwal, S, Heurich, M, English, J, O'Gorman, A, Suvitaival, T, Ahonen, L, Cannon, M, Lewis, G, Mattila, I, Scaife, C, Madden, S, Hyotylainen, T, Oresic, M, Zammit, S, Cagney, G, Cotter, DR & Brennan, L, 2019, ‘Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children’. Biological Psychiatry.

    Abstract

    Background: The identification of early biomarkers of psychotic experiences (PEs) is of interest as early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes. The current study investigated early lipidomic and coagulation pathway protein signatures of later PEs in subjects from the Avon Longitudinal Study of Parents and Children cohort.
    Methods: Plasma of 115 children (age 12) who were first identified as experiencing PEs at age 18 (48 cases and 67 controls) were assessed through integrated and targeted lipidomics and semi-targeted proteomics approaches. We assessed the lipids, LPCs (n=11) and PCs (n=61), and the protein members of the coagulation pathway (n=22) and integrated this data with complement pathway protein data already available on these subjects.
    Results: Twelve PCs, four LPCs and the coagulation protein plasminogen were altered between the control and PE group after correction for multiple comparisons. Lipidomic and proteomic datasets were integrated into a multivariate network displaying a strong relationship between most lipids that were significantly associated to PEs and plasminogen. Finally, an unsupervised clustering approach identified four different clusters with one of the clusters presenting the highest ratio cases:controls (P < 0.01) and associated with a higher concentration of smaller LDL cholesterol particles.
    Conclusions: Our findings indicate that the lipidome and proteome of subjects who report PEs at age 18 is already altered at age 12 indicating that metabolic dysregulation may contribute to an early vulnerability to PEs and suggesting cross-talk between these LPCs, PCs and coagulation and complement proteins.

    Full details in the University publications repository