Dr Philip Guthrie (course organiser), Dr Santi Rodriguez, Dr Tom Gaunt, Dr Lavinia Paternoster, Dr Nic Timpson.
22-23 April 2013
The aim of this course is to give an introduction to basic genetic concepts for use in genetic epidemiology. By the end of the course, participants should be able to:
Define basic genetic concepts such as gene, polymorphism, haplotype.
Understand Mendel's experiments and how these relate to what we know about Mendelian inheritance.
Describe the structure of genetic material, the process of cell division and DNA replication.
Describe studies which can be used to determine the size of the genetic component of a disease and the limitations of these studies.
Have an overall appreciation of how the science has developed, and its potential for the future.
This course is designed for epidemiologists and other researchers with little or no genetics knowledge, or those who simply want to refresh their genetics knowledge.
Topics to be covered include: Structure of DNA and chromosomes, gene expression, cell division and DNA replication, genetic recombination, mutations and polymorphisms, principles of Mendelian inheritance, single locus and polygenic models, familial aggregration, twin studies, adoption studies, the concept of heritablility, basic principles of linkage analysis, identity by state and by descent.
Thirteen hours with formal lectures, practical sessions, and group discussion work.
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