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Professor Andy Randall

Professor Andy Randall

Professor Andy Randall
PhD(Bristol), BSc (Bristol), MA (Cantab)

Professor in Applied Neurophysiology

Area of research

CNS Neurophysiology in health and disease

Office G29
Medical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

+44 (0) 117 331 1931

Summary

Our group is interested in the neurophysiological changes associated with neurological diseases, in particular Alzheimer's disease and schizophrenia. Experimentally the major part of our work involves a host of electrophysiological methods stretching from single channel recording, through cellular neurophysiology in vitro, to tetrode recordings of neuronal activity in vivo. We also utilise a number of optical methods including single cell imaging and photo-activated ion channels such as Channelrhodopsins.

We work in close association with the pharmaceutical industry who fund much of the work in the lab. We also have a host of collaborations within Bristol the research community.

Activities / Findings

  • Altered intrinsic excitability and ion channel complements in hippocampal neurones of Abeta peptide overproducing mice. Read more >
  • Novel long-lasting forms of intrinsic plasticity in hippocampal neurones. Read more >
  • Modifed synaptic plasticity in the mossy fibre pathway of Abeta peptide overproducing mice. Read more >
  • Induction of long-terrm synaptic plasticity by 5HT4 receptor agonists

Teaching

Final year undergraduate teaching, post-graduate course teaching, PhD supervision

Keywords

  • hippocampus
  • cortex
  • neuronal excitability
  • ion channels
  • channelrhodopsin
  • imaging

Skills

  • Alzheimer's disease
  • neurodegeneration
  • schizophrenia

Processes and functions

  • Memory
  • synaptic mechanisms
  • glial cells
  • network synchrony
  • intrinsic excitability
  • intrinsic plasticity

Methodologies

  • Electrophysiology
  • imaging

Memberships

Organisations

School of Physiology and Pharmacology

Other sites

Links

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Pfizer

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