Dr Jack Mellor

Research summary

Our ability to learn and remember information about our environment is thought to be underpinned by the process of synaptic plasticity. This means that during learning episodes, synapses are stimulated by specific patterns of activity that lead to the induction of synaptic plasticity. Subsequently, plasticity is expressed either by the insertion or removal of postsynaptic neurotransmitter receptors or by changes in the amount of neurotransmitter released from the presynaptic terminal.

Research in our laboratory is focused on what regulates the induction of synaptic plasticity and the mechanisms underlying its expression. Currently we are studying,

1) The patterns of activity that ...

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Selected publications

• Buchanan, K, Petrovic, M, Chamberlain, S, Marrion, N & Mellor, J 2010, ‘Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors is mediated by inhibition of SK channels’. Neuron, vol 68., pp. 948 - 963
• Rackham, O, Tsaneva-Atanasova, K, Ganesh, A & Mellor, J 2010, ‘A Ca2+-based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Postsynaptic Spines in the Hippocampus’. Frontiers in synaptic neuroscience, vol 2., pp. 1 - 12

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Recent publications

• Rocca, DL, Amici, M, Antoniou, A, Suarez, EMB, Halemani, ND, Murk, KT, McGarvey, J, Jaafari, N, Mellor, JR, Collingridge, GL & Hanley, JG 2013, ‘The small GTPase Arf1 regulates Arp2/3-mediated actin polymerization via PICK1 to control AMPA receptor trafficking, dendritic spine size and synaptic plasticity’. Neuron.
• Chamberlain, SEL, Sadowski, JHL, Ruivo, LMT, Atherton, LA & Mellor, JR 2013, ‘Long-Term Depression of Synaptic Kainate Receptors Reduces Excitability by Relieving Inhibition of the Slow Afterhyperpolarization’. Journal of Neuroscience.

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View complete publications list in the University of Bristol publications system